About: Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Diabetes mellitus, especially when complicated with decline of renal function due to diabetic nephropathy (DN), is associated with accumulation of Advanced Glycation End products (AGEs) exerting their adverse effects via Receptor of AGE (RAGE). Soluble RAGE (sRAGE) is a truncated form of RAGE functioning as an inhibitor of AGE-mediated signalling. We studied relationships between sRAGE, renal function and genetic variability in the AGER gene in diabetic subjects. Study comprised a total of 265 diabetics (type 1 or 2 or LADA) with normoalbuminuria (n=94) or DN (n=171). sRAGE (assessed by ELISA) was significantly higher in DN than normoalbuminuria subjects (P=0.007) and positively correlated with age, S-urea, S-creatinine and albuminuria and AGEs (determined spectrofluorimetrically), negatively with GFR (all P<0.05); however, multivariate regression revealed that GFR was the only independent variable associated with sRAGE (P=0.047). Diabetes mellitus, especially when complicated with decline of renal function due to diabetic nephropathy (DN), is associated with accumulation of Advanced Glycation End products (AGEs) exerting their adverse effects via Receptor of AGE (RAGE). Soluble RAGE (sRAGE) is a truncated form of RAGE functioning as an inhibitor of AGE-mediated signalling. We studied relationships between sRAGE, renal function and genetic variability in the AGER gene in diabetic subjects. Study comprised a total of 265 diabetics (type 1 or 2 or LADA) with normoalbuminuria (n=94) or DN (n=171). sRAGE (assessed by ELISA) was significantly higher in DN than normoalbuminuria subjects (P=0.007) and positively correlated with age, S-urea, S-creatinine and albuminuria and AGEs (determined spectrofluorimetrically), negatively with GFR (all P<0.05); however, multivariate regression revealed that GFR was the only independent variable associated with sRAGE (P=0.047). (en)
Title	Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene (en)
skos:prefLabel	Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene (en)
skos:notation	RIV/00216224:14110/08:00024150!RIV10-AV0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(KJB501620601), Z(MSM0021620807)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hertlová, Miluše Olšovský, Jindřich Zima, Tomáš Kaňková, Kateřina Krusová, Darja
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	395824
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/08:00024150
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	diabetes mellitus; soluble RAGE; AGEs; diabetic nephropathy; glomerular filtration rate (en)
http://linked.open.../riv/klicoveSlovo	AGEs glomerular filtration rate diabetes mellitus - insulin resistance - ethiopathogenesis - diagnostic criteria - late complications - advanced age - treatment soluble RAGE diabetic nephropathy
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[3DE37458B286]
http://linked.open...i/riv/nazevZdroje	Arch Physiol Biochem
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional analysis of the RAGE gene susceptibility haplotype and its role in the hyperglycemia-driven pathology
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	114
http://linked.open...iv/tvurceVysledku	Hertlová, Miluše Olšovský, Jindřich Zima, Tomáš Kaňková, Kateřina Krusová, Darja Kalousova, Marta
http://linked.open...n/vavai/riv/zamer	Metabolické, endokrinní a genetické aspekty prevence, diagnostiky a terapie kardiovaskulárních, cerebrovaskulárních a renovaskulárních onemocnění
issn	1381-3455
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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