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rdf:type
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Description
| - Common variable immunodeficiency (CVID) is primary hypogammaglobulinemia with unknown etiopathogenesis. Although various abnormalities of T- and B-cells were described, their pathogenetic roles are unclear. Markers associated with B-cell development were determined on B-lymphocytes (CD19+); T-lymphocyte development and activations markers were determined on CD4+ and CD8+ T-lymphocytes in 42 CVID patients and in 33 healthy controls. Abnormalities in CD4+ T-lymphocyte activation markers (increase in CD29, HLA-DR, CD45RO, decrease in CD27, CD62L, CD45RA) were particularly observed in patients with a decreased number of memory (CD27+) and mature (CD21+) B-cells (group Ia according to Freiburg classification), while abnormalities observed in CD8+ cells (increase in CD27 and CD28 and decrease in HLA-DR, CD57 and CD38) did not depend on grouping patients together according to B-lymphocyte developmental subpopulations.
- Common variable immunodeficiency (CVID) is primary hypogammaglobulinemia with unknown etiopathogenesis. Although various abnormalities of T- and B-cells were described, their pathogenetic roles are unclear. Markers associated with B-cell development were determined on B-lymphocytes (CD19+); T-lymphocyte development and activations markers were determined on CD4+ and CD8+ T-lymphocytes in 42 CVID patients and in 33 healthy controls. Abnormalities in CD4+ T-lymphocyte activation markers (increase in CD29, HLA-DR, CD45RO, decrease in CD27, CD62L, CD45RA) were particularly observed in patients with a decreased number of memory (CD27+) and mature (CD21+) B-cells (group Ia according to Freiburg classification), while abnormalities observed in CD8+ cells (increase in CD27 and CD28 and decrease in HLA-DR, CD57 and CD38) did not depend on grouping patients together according to B-lymphocyte developmental subpopulations. (en)
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Title
| - Age dependency and mutual relations in T- and B- lymphocyte abnormalities in CVID patients
- Age dependency and mutual relations in T- and B- lymphocyte abnormalities in CVID patients (en)
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skos:prefLabel
| - Age dependency and mutual relations in T- and B- lymphocyte abnormalities in CVID patients
- Age dependency and mutual relations in T- and B- lymphocyte abnormalities in CVID patients (en)
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skos:notation
| - RIV/00216224:14110/06:00018865!RIV10-MZ0-14110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/06:00018865
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Common variable immunodeficiency; T-lymphocyte subsets; B-lymphocyte subsets; differentiation antigens; age factor (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Bláha, Luděk
- Litzman, Jiří
- Lokaj, Jindřich
- Thon, Vojtěch
- Vlková, Marcela
- Svobodník, Adam
- Šárfyová, Mária
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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