About: Age dependency and mutual relations in T- and B- lymphocyte abnormalities in CVID patients

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Common variable immunodeficiency (CVID) is primary hypogammaglobulinemia with unknown etiopathogenesis. Although various abnormalities of T- and B-cells were described, their pathogenetic roles are unclear. Markers associated with B-cell development were determined on B-lymphocytes (CD19+); T-lymphocyte development and activations markers were determined on CD4+ and CD8+ T-lymphocytes in 42 CVID patients and in 33 healthy controls. Abnormalities in CD4+ T-lymphocyte activation markers (increase in CD29, HLA-DR, CD45RO, decrease in CD27, CD62L, CD45RA) were particularly observed in patients with a decreased number of memory (CD27+) and mature (CD21+) B-cells (group Ia according to Freiburg classification), while abnormalities observed in CD8+ cells (increase in CD27 and CD28 and decrease in HLA-DR, CD57 and CD38) did not depend on grouping patients together according to B-lymphocyte developmental subpopulations. Common variable immunodeficiency (CVID) is primary hypogammaglobulinemia with unknown etiopathogenesis. Although various abnormalities of T- and B-cells were described, their pathogenetic roles are unclear. Markers associated with B-cell development were determined on B-lymphocytes (CD19+); T-lymphocyte development and activations markers were determined on CD4+ and CD8+ T-lymphocytes in 42 CVID patients and in 33 healthy controls. Abnormalities in CD4+ T-lymphocyte activation markers (increase in CD29, HLA-DR, CD45RO, decrease in CD27, CD62L, CD45RA) were particularly observed in patients with a decreased number of memory (CD27+) and mature (CD21+) B-cells (group Ia according to Freiburg classification), while abnormalities observed in CD8+ cells (increase in CD27 and CD28 and decrease in HLA-DR, CD57 and CD38) did not depend on grouping patients together according to B-lymphocyte developmental subpopulations. (en)
Title	Age dependency and mutual relations in T- and B- lymphocyte abnormalities in CVID patients Age dependency and mutual relations in T- and B- lymphocyte abnormalities in CVID patients (en)
skos:prefLabel	Age dependency and mutual relations in T- and B- lymphocyte abnormalities in CVID patients Age dependency and mutual relations in T- and B- lymphocyte abnormalities in CVID patients (en)
skos:notation	RIV/00216224:14110/06:00018865!RIV10-MZ0-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR7981)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Vlková, Marcela Thon, Vojtěch Lokaj, Jindřich Litzman, Jiří Bláha, Luděk Šárfyová, Mária Svobodník, Adam
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	464303
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/06:00018865
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Common variable immunodeficiency; T-lymphocyte subsets; B-lymphocyte subsets; differentiation antigens; age factor (en)
http://linked.open.../riv/klicoveSlovo	Common variable immunodeficiency B-lymphocyte subsets T-lymphocyte subsets differentiation antigens age factor
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[0F5D623D5B02]
http://linked.open...i/riv/nazevZdroje	Clin Exp Immunol
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Lymphocyte subpopulatins in patients with humoral immunodeficiencies
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	143
http://linked.open...iv/tvurceVysledku	Bláha, Luděk Litzman, Jiří Lokaj, Jindřich Thon, Vojtěch Vlková, Marcela Svobodník, Adam Šárfyová, Mária
http://linked.open...ain/vavai/riv/wos	000234647300023
issn	0009-9104
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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