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Description
  • Methamphetamine represents a significant drug abuse problem in many European countries including the Czech republic. Studies in human liver microsomes have shown that crucial metabolic reactions of MeAmp are catalyzed by CYP2D6; furthermore, some amphetamine analogues were reported as inhibitors of CYP2D6 (Wu et. al., 1997). The aim of the study was to ascertain the influence of acute and repeated pretreatment of rats with various doses of methamphetamine on metabolic activity of CYP2D1/2 (correlate of human CYP2D6) in the isolated perfused rat liver.
  • Methamphetamine represents a significant drug abuse problem in many European countries including the Czech republic. Studies in human liver microsomes have shown that crucial metabolic reactions of MeAmp are catalyzed by CYP2D6; furthermore, some amphetamine analogues were reported as inhibitors of CYP2D6 (Wu et. al., 1997). The aim of the study was to ascertain the influence of acute and repeated pretreatment of rats with various doses of methamphetamine on metabolic activity of CYP2D1/2 (correlate of human CYP2D6) in the isolated perfused rat liver. (cs)
  • Methamphetamine increases CYP2D1/2 activity in isolated perfused rat liver (en)
Title
  • Methamphetamine increases CYP2D1/2 activity in isolated perfused rat liver (en)
  • Mmetamfetamin zvyšuje aktivtu CYP2D v systému izolovaných perfundovaných jater
  • Mmetamfetamin zvyšuje aktivtu CYP2D v systému izolovaných perfundovaných jater (cs)
skos:prefLabel
  • Methamphetamine increases CYP2D1/2 activity in isolated perfused rat liver (en)
  • Mmetamfetamin zvyšuje aktivtu CYP2D v systému izolovaných perfundovaných jater
  • Mmetamfetamin zvyšuje aktivtu CYP2D v systému izolovaných perfundovaných jater (cs)
skos:notation
  • RIV/00216224:14110/04:00010750!RIV08-MSM-14110___
http://linked.open.../vavai/riv/strany
  • 19-19
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 141100001)
http://linked.open...iv/cisloPeriodika
  • Suppl. 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 573832
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/04:00010750
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • methamphetamine; rat; liver (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [52F96CCC8D2D]
http://linked.open...i/riv/nazevZdroje
  • Psychiatrie
http://linked.open...in/vavai/riv/obor
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http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 8
http://linked.open...iv/tvurceVysledku
  • Dostálek, Miroslav
  • Juřica, Jan
  • Tomandl, Josef
  • McCaskey Hadašová, Eva
  • Minaříková, Veronika
http://linked.open...n/vavai/riv/zamer
issn
  • 1211-7579
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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