About: T-lymphocyte subsets and function in IgA deficiency

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Common variable immunodeficiency (CVID) and IgA deficiency (IgAD) are primary humoral immune deficiencies with probably similar genetic background, but clinical and laboratory manifestation is much more severe in CVID than in IgAD. The aim of this study was to determine whether some abnormalities in T-lymphocyte subsets or function previously observed in CVID are also present in IgAD patients. T-lymphocyte subsets (CD3, CD4, CD8, CD4CD45RA, CD4CD45RO, CD8CD57) were studied in 61 adult IgAD patients and 43 control healthy persons. A significant decrease in CD4+ and increase in CD8+ and CD8+CD57+ lymphocytes was observed, while no significant changes in the proportion of CD45RA+ or CD45RO+ in CD4 cells were detected. No significant changes in lymphocyte proliferation after stimulation with Phytohaemagglutinin, Concanavalin-A or tetanic toxoid were observed in 15 adult IgAD patients compared to 15 controls. Our study shows, that T-lymphocyte abnormalities are also present in IgAD patient, although not i Common variable immunodeficiency (CVID) and IgA deficiency (IgAD) are primary humoral immune deficiencies with probably similar genetic background, but clinical and laboratory manifestation is much more severe in CVID than in IgAD. The aim of this study was to determine whether some abnormalities in T-lymphocyte subsets or function previously observed in CVID are also present in IgAD patients. T-lymphocyte subsets (CD3, CD4, CD8, CD4CD45RA, CD4CD45RO, CD8CD57) were studied in 61 adult IgAD patients and 43 control healthy persons. A significant decrease in CD4+ and increase in CD8+ and CD8+CD57+ lymphocytes was observed, while no significant changes in the proportion of CD45RA+ or CD45RO+ in CD4 cells were detected. No significant changes in lymphocyte proliferation after stimulation with Phytohaemagglutinin, Concanavalin-A or tetanic toxoid were observed in 15 adult IgAD patients compared to 15 controls. Our study shows, that T-lymphocyte abnormalities are also present in IgAD patient, although not i (en)
Title	T-lymphocyte subsets and function in IgA deficiency T-lymphocyte subsets and function in IgA deficiency (en)
skos:prefLabel	T-lymphocyte subsets and function in IgA deficiency T-lymphocyte subsets and function in IgA deficiency (en)
skos:notation	RIV/00216224:14110/01:00006090!RIV/2003/MZ0/141103/N
http://linked.open.../vavai/riv/strany	345
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NI4703)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Thon, Vojtěch Lokaj, Jindřich Litzman, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	698864
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/01:00006090
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	IgA deficiency, T-lymphocytes, lymphocyte subsets (en)
http://linked.open.../riv/klicoveSlovo	IgA deficiency T-lymphocytes lymphocyte subsets
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[5B348438427A]
http://linked.open...i/riv/nazevZdroje	Scripta Medica
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Immunoregulatory defects in patients with humoral immunodeficiencies
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	74
http://linked.open...iv/tvurceVysledku	Litzman, Jiří Lokaj, Jindřich Thon, Vojtěch Štouračová, Martina Krejčí, Marcela
issn	1211-3395
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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