About: Effects of psychopharmacotherapy on phenotypic expression of cytochrome P450 2D6 in patients genotyped for CYP2D6 mutations     Goto   Sponge   Distinct   Permalink

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Description
  • Twenty psychiatric patients were investigated for their CYP2D6 genotype and phenotype. Eight patients were pretreated with CYP2D6 substrate drugs, another 12 were therapy free. Genotyping with PCR for mutations in exon 3, 4 and 5 of CYP2D6 gene detected 65% of patients as heterozygously mutated in exon 4. The phenotyping test showed a significantly higher occurence of poor metabolizers in patients
  • Twenty psychiatric patients were investigated for their CYP2D6 genotype and phenotype. Eight patients were pretreated with CYP2D6 substrate drugs, another 12 were therapy free. Genotyping with PCR for mutations in exon 3, 4 and 5 of CYP2D6 gene detected 65% of patients as heterozygously mutated in exon 4. The phenotyping test showed a significantly higher occurence of poor metabolizers in patients (en)
  • U dvaceti psychiatrických pacientů byly sledovány jejich genotypy a fenotypy. (cs)
Title
  • Effects of psychopharmacotherapy on phenotypic expression of cytochrome P450 2D6 in patients genotyped for CYP2D6 mutations
  • Effects of psychopharmacotherapy on phenotypic expression of cytochrome P450 2D6 in patients genotyped for CYP2D6 mutations (en)
  • Effects of psychopharmacotherapy on phenotypic expression of cytochrome P450 2D6 in patients genotyped for CYP2D6 mutations (cs)
skos:prefLabel
  • Effects of psychopharmacotherapy on phenotypic expression of cytochrome P450 2D6 in patients genotyped for CYP2D6 mutations
  • Effects of psychopharmacotherapy on phenotypic expression of cytochrome P450 2D6 in patients genotyped for CYP2D6 mutations (en)
  • Effects of psychopharmacotherapy on phenotypic expression of cytochrome P450 2D6 in patients genotyped for CYP2D6 mutations (cs)
skos:notation
  • RIV/00216224:14110/00:00002245!RIV09-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 141100001)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 709845
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/00:00002245
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Pharmacogenetics; CYP2D6 polymorphism; Dextromethorphan; Psychotropics (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [41A656FDA89F]
http://linked.open...i/riv/nazevZdroje
  • Human Psychopharmacol.
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 2000
http://linked.open...iv/tvurceVysledku
  • Češková, Eva
  • Vojtíšková, Marie
  • McCaskey Hadašová, Eva
  • Hyksová, Marie
  • Starobova, Olga
http://linked.open...ain/vavai/riv/wos
  • 000087981300012
http://linked.open...n/vavai/riv/zamer
issn
  • 0885-6222
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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