About: Electrochemical Study of Doxorubicin Interaction with Different Sequences of Double Stranded Oligonucleotides, Part II

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.electrochemsci.org/papers/vol7/7010034.pdf
Description	Interaction of low molecular weight compounds with DNA is one of general mechanisms utilized for an effective anticancer therapy. The anthracycline doxorubicin is one of the drugs that represent the compound with such effect. In our previous work [Hynek et al., Int. J. Electrochem, Sci. 7 (2012) xx] the electrochemical behaviour of doxorubicin interaction with single stranded ODN by using adsorptive transfer stripping square wave voltammetry was described. This paper is focused on the study of interaction of doxorubicin with double stranded ODNs (dsODNs) using the same technique. Here, we used four dsODNs possessing different primary structuresand observed the changes in their electrochemical behaviour after their treatment with three concentrations of doxorubicin for 5 hours. The changes found are discussed and differences in behaviours of individual dsODNs described and associated with their structure. Interaction of low molecular weight compounds with DNA is one of general mechanisms utilized for an effective anticancer therapy. The anthracycline doxorubicin is one of the drugs that represent the compound with such effect. In our previous work [Hynek et al., Int. J. Electrochem, Sci. 7 (2012) xx] the electrochemical behaviour of doxorubicin interaction with single stranded ODN by using adsorptive transfer stripping square wave voltammetry was described. This paper is focused on the study of interaction of doxorubicin with double stranded ODNs (dsODNs) using the same technique. Here, we used four dsODNs possessing different primary structuresand observed the changes in their electrochemical behaviour after their treatment with three concentrations of doxorubicin for 5 hours. The changes found are discussed and differences in behaviours of individual dsODNs described and associated with their structure. (en)
Title	Electrochemical Study of Doxorubicin Interaction with Different Sequences of Double Stranded Oligonucleotides, Part II Electrochemical Study of Doxorubicin Interaction with Different Sequences of Double Stranded Oligonucleotides, Part II (en)
skos:prefLabel	Electrochemical Study of Doxorubicin Interaction with Different Sequences of Double Stranded Oligonucleotides, Part II Electrochemical Study of Doxorubicin Interaction with Different Sequences of Double Stranded Oligonucleotides, Part II (en)
skos:notation	RIV/00216208:11310/12:10126257!RIV13-GA0-11310___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(GA102/08/1546), P(GAP301/10/0356)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Stiborová, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	133885
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/12:10126257
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cancer-cells; elimination voltammetry; square-wave voltammetry; DNA hybridization assays; pyrolytic-graphite electrode; DNA; adriamycin; adsorptive transfer stripping technique; square wave voltammetry; hetero-nucleotides; doxorubicin; intercalating drug (en)
http://linked.open.../riv/klicoveSlovo	square wave voltammetry DNA square-wave voltammetry DNA hybridization assays adriamycin adsorptive transfer stripping technique hetero-nucleotides intercalating drug pyrolytic-graphite electrode doxorubicin elimination voltammetry cancer-cells
http://linked.open...odStatuVydavatele	RS - Srbská republika
http://linked.open...ontrolniKodProRIV	[339D40545E08]
http://linked.open...i/riv/nazevZdroje	International Journal of Electrochemical Science
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology Study of contribution of different DNA-damaging mechanisms to toxicity of cytostatics to human chemosensitive and chemoresistant neuroblastomas Miniaturized intelligent systems and nanostructured elektrodes for chemical, biological, and pharmaceutical applications (NANIMEL)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Eckschlager, Tomáš Hubálek, Jaromír Hynek, David Kizek, René Krejčová, Ludmila Sochor, Jiří Stiborová, Marie Trnková, Libuše Zítka, Ondřej
http://linked.open...ain/vavai/riv/wos	000302723700003
issn	1452-3981
number of pages	16 (xsd:int)
http://localhost/t...ganizacniJednotka	11310

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