About: The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti

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About: The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The recombinant cathepsin B2 from Trichobilharzia regenti was produced and characterised. Its presence was confirmed in extracts from cercariae and schistosomula. Cross-reactivity was observed between T. regenti and S. mansoni cathepsins B2 in extracts of cercariae, schistosomula or adults. In T. regenti, the antisera localised the enzyme to post-acetabular penetration glands of cercariae implying an important role in the penetration of host skin. Elastinolytic activity suggests that the enzyme might functionally substitute the histolytic role of the serine class elastase known from S. mansoni and Schistosoma haematobium. The recombinant cathepsin B2 from Trichobilharzia regenti was produced and characterised. Its presence was confirmed in extracts from cercariae and schistosomula. Cross-reactivity was observed between T. regenti and S. mansoni cathepsins B2 in extracts of cercariae, schistosomula or adults. In T. regenti, the antisera localised the enzyme to post-acetabular penetration glands of cercariae implying an important role in the penetration of host skin. Elastinolytic activity suggests that the enzyme might functionally substitute the histolytic role of the serine class elastase known from S. mansoni and Schistosoma haematobium. (en)
Title	The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti (en)
skos:prefLabel	The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti (en)
skos:notation	RIV/00216208:11310/09:10000029!RIV10-GA0-11310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA206/07/0233), P(GP524/04/P082), P(LC06009), Z(MSM0021620828)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kašný, Martin Horák, Petr Dolečková, Kateřina Mikeš, Libor Jedelský, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	315713
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/09:10000029
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Trematoda; cathepsin B; protease; penetration gland; skin; histolysis; Schistosoma; Trichobilharzia; cercaria (en)
http://linked.open.../riv/klicoveSlovo	histolysis penetration gland cathepsin B skin protease Schistosoma Trichobilharzia Trematoda cercaria
http://linked.open...odStatuVydavatele	AU - Australské společenství
http://linked.open...ontrolniKodProRIV	[1C0E9B8CF7D9]
http://linked.open...i/riv/nazevZdroje	International Journal for Parasitology
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for molecular ecology of vectors and pathogens Biochemical, ultrastructural and partial proteomic analysis of the penetration apparatus of bird schistosome cercariae Biochemical and molecular characterization of cathepsins from penetrating cercariae of three trematode species
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	39
http://linked.open...iv/tvurceVysledku	Dolečková, Kateřina Dvořák, Jan Horák, Petr Jedelský, Petr Kašný, Martin Mikeš, Libor Mountford, Adrian P. Cartwright, Jared Craik, Charles S. Schneider, Eric L.
http://linked.open...ain/vavai/riv/wos	000262770200008
http://linked.open...n/vavai/riv/zamer	Ekologické procesy v evoluci modelových skupin organismů
issn	0020-7519
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	11310

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