About: Effect of selected catechins on doxorubicin antiproliferative efficacy and hepatotoxicity in vitro

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.degruyter.com/view/j/acph.2014.64.issue-2/acph-2014-0018/acph-2014-0018.xml
Description	Catechins may influence both desirable and undesirable effects of many drugs. In this study, the in vitro effect of (+)-catechin, (-)-epicatechin, (-)-epigallocatechin, (-)-epicatechin gallate, and (-)-epigallocatechin gallate (EGCG) on the efficacy of anticancer drug doxorubicin (DOX) was studied in HCT-8 cancer cells. Rat hepatocytes were used to study the influence of EGCG on DOX hepatotoxicity. Cell proliferation and viability were studied by 3-[4,5-dimethylthiazol- 2-yl]-2,5-diphenyl tetrazolium bromide and neutral red uptake test assays. Formation of reactive oxygen species (ROS) was determined using the dichlorofluorescein assay. All of the studied catechins (1-25 mu mol L-1) had no effect on the proliferation of intestinal cancer cells and did not affect the antiproliferative effect of DOX (1-8 mu mol L-1) in these cells. Moreover, EGCG at 25 mu mol L-1 increased the viability of isolated hepatocytes and significantly protected these cells against DOX-induced toxicity and ROS production. Consumption of EGCG during DOX therapy seems to be safe and beneficial, since EGCG does not decrease DOX anticancer efficacy and could ameliorate DOX hepatotoxicity. Catechins may influence both desirable and undesirable effects of many drugs. In this study, the in vitro effect of (+)-catechin, (-)-epicatechin, (-)-epigallocatechin, (-)-epicatechin gallate, and (-)-epigallocatechin gallate (EGCG) on the efficacy of anticancer drug doxorubicin (DOX) was studied in HCT-8 cancer cells. Rat hepatocytes were used to study the influence of EGCG on DOX hepatotoxicity. Cell proliferation and viability were studied by 3-[4,5-dimethylthiazol- 2-yl]-2,5-diphenyl tetrazolium bromide and neutral red uptake test assays. Formation of reactive oxygen species (ROS) was determined using the dichlorofluorescein assay. All of the studied catechins (1-25 mu mol L-1) had no effect on the proliferation of intestinal cancer cells and did not affect the antiproliferative effect of DOX (1-8 mu mol L-1) in these cells. Moreover, EGCG at 25 mu mol L-1 increased the viability of isolated hepatocytes and significantly protected these cells against DOX-induced toxicity and ROS production. Consumption of EGCG during DOX therapy seems to be safe and beneficial, since EGCG does not decrease DOX anticancer efficacy and could ameliorate DOX hepatotoxicity. (en)
Title	Effect of selected catechins on doxorubicin antiproliferative efficacy and hepatotoxicity in vitro Effect of selected catechins on doxorubicin antiproliferative efficacy and hepatotoxicity in vitro (en)
skos:prefLabel	Effect of selected catechins on doxorubicin antiproliferative efficacy and hepatotoxicity in vitro Effect of selected catechins on doxorubicin antiproliferative efficacy and hepatotoxicity in vitro (en)
skos:notation	RIV/00216208:11160/14:10281583!RIV15-MSM-11160___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(EE2.3.30.0022), P(GBP303/12/G163)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Rudolfová, Petra Matoušková, Petra Boušová, Iva Skálová, Lenka Hanušová, Veronika Bártíková, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	13485
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/14:10281583
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	doxorubicin; hepatocytes; HCT-8 cells; chemoprevention; epigallocatechin gallate (en)
http://linked.open.../riv/klicoveSlovo	HCT-8 cells chemoprevention epigallocatechin gallate doxorubicin hepatocytes
http://linked.open...odStatuVydavatele	CR - Kostarická republika
http://linked.open...ontrolniKodProRIV	[EC47CE4EE605]
http://linked.open...i/riv/nazevZdroje	Acta Pharmaceutica
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre of drug-dietary supplements interactions and nutrigenetics Support of establishment, development, and mobility of quality research teams at the Charles University
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	64
http://linked.open...iv/tvurceVysledku	Boušová, Iva Hanušová, Veronika Skálová, Lenka Matoušková, Petra Bártíková, Hana Rudolfová, Petra
http://linked.open...ain/vavai/riv/wos	000337705100005
issn	1330-0075
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.2478/acph-2014-0018
http://localhost/t...ganizacniJednotka	11160

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