About: From pyridinium-based to centrally active acetylcholinesterase reactivators

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ingentaconnect.com/content/ben/mrmc/2014/00000014/00000003/art00001
Description	Organophosphates are used as pesticides or misused as warfare nerve agents. Exposure to them can be fatal and death is usually caused by respiratory arrest. For almost six decades, pyridinium oximes represent a therapeutic tool used for the management of poisoning with organophosphorus (OP) compounds. However, these compounds possess several drawbacks. Firstly, they are inefficient in the restoration of brain acetylcholinesterase (AChE) activity due to a hard blood-brain barrier penetration. Secondly, there is no broad-spectrum AChE reactivator. Lastly, none of the oximes can reactivate %22aged%22 AChE. In this context, uncharged reactivators represent a new hope in a way of increased bioavailability in the central compartment and better therapeutic management of the OP poisoning. Organophosphates are used as pesticides or misused as warfare nerve agents. Exposure to them can be fatal and death is usually caused by respiratory arrest. For almost six decades, pyridinium oximes represent a therapeutic tool used for the management of poisoning with organophosphorus (OP) compounds. However, these compounds possess several drawbacks. Firstly, they are inefficient in the restoration of brain acetylcholinesterase (AChE) activity due to a hard blood-brain barrier penetration. Secondly, there is no broad-spectrum AChE reactivator. Lastly, none of the oximes can reactivate %22aged%22 AChE. In this context, uncharged reactivators represent a new hope in a way of increased bioavailability in the central compartment and better therapeutic management of the OP poisoning. (en)
Title	From pyridinium-based to centrally active acetylcholinesterase reactivators From pyridinium-based to centrally active acetylcholinesterase reactivators (en)
skos:prefLabel	From pyridinium-based to centrally active acetylcholinesterase reactivators From pyridinium-based to centrally active acetylcholinesterase reactivators (en)
skos:notation	RIV/00216208:11160/14:10281199!RIV15-MSM-11160___
http://linked.open...avai/riv/aktivita	I S Z
http://linked.open...avai/riv/aktivity	I, S, Z(MSM0021620849)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Nguyen, Thuy Duong Chlupáčová, Marta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	17572
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/14:10281199
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	uncharged reactivator; trimedoxime; reactivator; pralidoxime; pyridinium oximes; organophosphorus compounds; HI-6; Acetylcholinesterase (en)
http://linked.open.../riv/klicoveSlovo	uncharged reactivator pralidoxime Acetylcholinesterase HI-6 trimedoxime pyridinium oximes reactivator organophosphorus compounds
http://linked.open...odStatuVydavatele	AE - Stát Spojené arabské emiráty
http://linked.open...ontrolniKodProRIV	[D6E97DEEECF0]
http://linked.open...i/riv/nazevZdroje	Mini reviews in medicinal chemistry
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Doležal, Rafael Kuča, Kamil Musílek, Kamil Jun, Daniel Soukup, Ondřej Korábečný, Jan Špilovská, Katarína Nepovimová, Eugenie Kučerová-Chlupáčová, Marta Andrš, Martin Nguyen, Thuy Duong
http://linked.open...ain/vavai/riv/wos	000340832800001
http://linked.open...n/vavai/riv/zamer	Neuropsychiatrické aspekty neurodegenerativních onemocnění
issn	1389-5575
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.2174/1389557514666140219103138
http://localhost/t...ganizacniJednotka	11160

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