About: Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities     Goto   Sponge   Distinct   Permalink

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  • Eleven alkaloids were isolated from fresh bulbs of Chlidanthus fragrans. The chemical structures were elucidated by MS, and 1D and 2D NMR spectroscopic experiments. All compounds were evaluated for their erythrocytic acetylcholinesterase and serum butyrylcholinesterase inhibition activity using Ellman's method. In the prolyl oligopeptidase assay, Z-Gly-Pro-P-nitroaniline was used as substrate. In biological assays, only the crinine type Amaryllidaceae alkaloid undulatine showed promising acetylcholinesterase and prolyl oligopeptidase inhibition activity. Other isolated compounds were considered inactive.
  • Eleven alkaloids were isolated from fresh bulbs of Chlidanthus fragrans. The chemical structures were elucidated by MS, and 1D and 2D NMR spectroscopic experiments. All compounds were evaluated for their erythrocytic acetylcholinesterase and serum butyrylcholinesterase inhibition activity using Ellman's method. In the prolyl oligopeptidase assay, Z-Gly-Pro-P-nitroaniline was used as substrate. In biological assays, only the crinine type Amaryllidaceae alkaloid undulatine showed promising acetylcholinesterase and prolyl oligopeptidase inhibition activity. Other isolated compounds were considered inactive. (en)
Title
  • Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities
  • Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities (en)
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  • Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities
  • Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities (en)
skos:notation
  • RIV/00216208:11160/13:10145863!RIV14-MSM-11160___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(EE2.3.20.0235), P(GAP303/11/1907), S
http://linked.open...iv/cisloPeriodika
  • 11
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 60107
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  • RIV/00216208:11160/13:10145863
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  • prolyl oligopeptidase; butyrylcholinesterase; acetylcholinesterase; deoxypretazettine; Amaryllidaceae; Chlidanthus fragrans (en)
http://linked.open.../riv/klicoveSlovo
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  • GB - Spojené království Velké Británie a Severního Irska
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  • [BA14D3B71354]
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  • Natural product communications
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http://linked.open...v/svazekPeriodika
  • 8
http://linked.open...iv/tvurceVysledku
  • Hrabinová, Martina
  • Kuča, Kamil
  • Kuneš, Jiří
  • Cahlíková, Lucie
  • Chlebek, Jakub
  • Jun, Daniel
  • Kulhánková, Andrea
  • Macáková, Kateřina
  • Opletal, Lubomír
  • Novák, Zdeněk
  • Benešová, Nina
http://linked.open...ain/vavai/riv/wos
  • 000326859300010
issn
  • 1934-578X
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  • 11160
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