About: Effects of conventional CPB and mini-CPB on neutrophils CD162, CD166 and CD195 expression

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About: Effects of conventional CPB and mini-CPB on neutrophils CD162, CD166 and CD195 expression Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://cardiologyacademicpress.com/soap/pdf/delme_2398_54078f638edb71.81094665.pdf
Description	Objective: Cardiac surgery is known to trigger the systemic inflammatory response. While the use of conventional cardiopulmonary bypass (CPB) results in profound inflammation, modified mini-CPB is considered less harmful. We evaluated effects of cardiac surgery on the expression of CD162, CD166, CD195 molecules and their association with the type of CPB used. Methods and Results: 24 patients were enrolled in our study. 12 of them were operated using conventional CPB while other 12 patients underwent surgery with mini-CPB. Blood samples were analysed by flow cytometry. We observed the significant increase in CD162, CD195 MFI that peaked instantly after surgery and normalized to the baseline value on the 1st day, whereas CD166 was initially down regulated and its MFI value increased to the baseline in the next few days. Conclusion: We observed immediate changes in the expression of CD162, CD166, and CD195 molecules on neutrophils after surgery in both study groups of patients. The intensity of observed changes was significantly greater in the group of patients who underwent conventional CPB compared to patients who underwent mini-CPB cardiac surgery. Objective: Cardiac surgery is known to trigger the systemic inflammatory response. While the use of conventional cardiopulmonary bypass (CPB) results in profound inflammation, modified mini-CPB is considered less harmful. We evaluated effects of cardiac surgery on the expression of CD162, CD166, CD195 molecules and their association with the type of CPB used. Methods and Results: 24 patients were enrolled in our study. 12 of them were operated using conventional CPB while other 12 patients underwent surgery with mini-CPB. Blood samples were analysed by flow cytometry. We observed the significant increase in CD162, CD195 MFI that peaked instantly after surgery and normalized to the baseline value on the 1st day, whereas CD166 was initially down regulated and its MFI value increased to the baseline in the next few days. Conclusion: We observed immediate changes in the expression of CD162, CD166, and CD195 molecules on neutrophils after surgery in both study groups of patients. The intensity of observed changes was significantly greater in the group of patients who underwent conventional CPB compared to patients who underwent mini-CPB cardiac surgery. (en)
Title	Effects of conventional CPB and mini-CPB on neutrophils CD162, CD166 and CD195 expression Effects of conventional CPB and mini-CPB on neutrophils CD162, CD166 and CD195 expression (en)
skos:prefLabel	Effects of conventional CPB and mini-CPB on neutrophils CD162, CD166 and CD195 expression Effects of conventional CPB and mini-CPB on neutrophils CD162, CD166 and CD195 expression (en)
skos:notation	RIV/00216208:11150/14:10272002!RIV15-MSM-11150___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Koláčková, Martina Holmannová, Drahomíra Krejsek, Jan Manďák, Jiří Andrýs, Ctirad Kuneš, Pavel Holubcová, Zdeňka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	13701
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/14:10272002
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CD195; CD166; CD162; neutrophils; cardiopulmonary bypass (en)
http://linked.open.../riv/klicoveSlovo	CD162 CD166 CD195 neutrophils cardiopulmonary bypass
http://linked.open...odStatuVydavatele	CA - Kanada
http://linked.open...ontrolniKodProRIV	[528516E400A1]
http://linked.open...i/riv/nazevZdroje	Experimental and Clinical Cardiology
http://linked.open...in/vavai/riv/obor	FN
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Andrýs, Ctirad Krejsek, Jan Koláčková, Martina Manďák, Jiří Kuneš, Pavel Holubcová, Zdeňka Holmannová, Drahomíra
issn	1205-6626
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	11150

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