About: Irradiation of adult human dental pulp stem cells provokes activation of p53, cell cycle arrest, and senescence but not apoptosis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Adult human dental pulp contains stem cells (DPSCs) that are capable of differentiation into osteoblasts, odontoblasts,adipocytes, and neuronal-like cells. Because these cells have potential use in tissue regeneration, herein we characterized the response of DPSC lines to ionizing radiation (IR). These DPSC lines have been developed from the extracted molars of healthy donors. DPSCs were cultivated in a unique media supplemented with epidermal growth factor (EGF) and platelet-derived growth factor (PDGF). Since tissue homeostasis depends on a precise balance among cell proliferation, senescence, and cell death, we explored the effects of IR (2-20 Gy) on the proliferative activity of DPSCs and the molecular pathways involved. Even the highest dose used (20 Gy) did notinduce DPSC apoptosis. After irradiation with doses of 6 and 20 Gy, DPSCs accumulated in the G2 phase of the cell cycle. Adult human dental pulp contains stem cells (DPSCs) that are capable of differentiation into osteoblasts, odontoblasts,adipocytes, and neuronal-like cells. Because these cells have potential use in tissue regeneration, herein we characterized the response of DPSC lines to ionizing radiation (IR). These DPSC lines have been developed from the extracted molars of healthy donors. DPSCs were cultivated in a unique media supplemented with epidermal growth factor (EGF) and platelet-derived growth factor (PDGF). Since tissue homeostasis depends on a precise balance among cell proliferation, senescence, and cell death, we explored the effects of IR (2-20 Gy) on the proliferative activity of DPSCs and the molecular pathways involved. Even the highest dose used (20 Gy) did notinduce DPSC apoptosis. After irradiation with doses of 6 and 20 Gy, DPSCs accumulated in the G2 phase of the cell cycle. (en)
Title	Irradiation of adult human dental pulp stem cells provokes activation of p53, cell cycle arrest, and senescence but not apoptosis Irradiation of adult human dental pulp stem cells provokes activation of p53, cell cycle arrest, and senescence but not apoptosis (en)
skos:prefLabel	Irradiation of adult human dental pulp stem cells provokes activation of p53, cell cycle arrest, and senescence but not apoptosis Irradiation of adult human dental pulp stem cells provokes activation of p53, cell cycle arrest, and senescence but not apoptosis (en)
skos:notation	RIV/00216208:11150/10:10081061!RIV11-GA0-11150___
http://linked.open...avai/riv/aktivita	P V
http://linked.open...avai/riv/aktivity	P(GA304/09/1568), P(NR9182), V
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Víšek, Benjamín Ćmielová, Jana Muthná, Darina Řezáčová, Martina Havelek, Radim Filip, Stanislav Soukup, Tomáš Mokrý, Jaroslav Jiroutová, Alena Suchánek, Jakub
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	264944
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/10:10081061
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	senescence; cell cycle arest; p53; irradiation; Human Dental Pulp Stem Cells (en)
http://linked.open.../riv/klicoveSlovo	p53 senescence Human Dental Pulp Stem Cells cell cycle arest irradiation
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[CEEDDF74BBEE]
http://linked.open...i/riv/nazevZdroje	Stem Cells and Development
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	10 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Chatacteristic of resistance of adult stem cells to genotoxic stress Isolation, cultivation, differentiation and phenotypic characterization of dental pulp stem cells
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Filip, Stanislav Havelek, Radim Mokrý, Jaroslav Muthná, Darina Soukup, Tomáš Suchánek, Jakub Vávrová, Jiřina Řezáčová, Martina Jiroutová, Alena Ćmielová, Jana Víšek, Benjamín English, Denis
http://linked.open...ain/vavai/riv/wos	000284626400004
issn	1547-3287
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11150

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