About: Type and distribution of indomethacin-induced lesions in the gastrointestinal tract of rat

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The therapy with non-steroidal anti-inflammatory drugs is often accompanied with adverse effects in gastrointestinal tract. Aim of this experimental study was to define the time range of the creation of indomethacin-induced gastrointestinal lesions in rat. The gradual development of lesions was observed 6 hours in stomach and 24-72 hours in the intestine after the indomethacin administration. Not only the gradual development of pathophysiological alterations was observed but also the reparative phase (in the stomach). 24 hours seem to be advisable time suitable for the evaluation of the probiotics effecs as a potential therapy on the indomethacine-induced gastrointestinal lesions in rats. The therapy with non-steroidal anti-inflammatory drugs is often accompanied with adverse effects in gastrointestinal tract. Aim of this experimental study was to define the time range of the creation of indomethacin-induced gastrointestinal lesions in rat. The gradual development of lesions was observed 6 hours in stomach and 24-72 hours in the intestine after the indomethacin administration. Not only the gradual development of pathophysiological alterations was observed but also the reparative phase (in the stomach). 24 hours seem to be advisable time suitable for the evaluation of the probiotics effecs as a potential therapy on the indomethacine-induced gastrointestinal lesions in rats. (en)
Title	Type and distribution of indomethacin-induced lesions in the gastrointestinal tract of rat Type and distribution of indomethacin-induced lesions in the gastrointestinal tract of rat (en)
skos:prefLabel	Type and distribution of indomethacin-induced lesions in the gastrointestinal tract of rat Type and distribution of indomethacin-induced lesions in the gastrointestinal tract of rat (en)
skos:notation	RIV/00216208:11150/09:00208621!RIV10-MZ0-11150___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/08/0535), Z(MZ0FNHK2005)
http://linked.open...iv/cisloPeriodika	Suppl. 1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Bureš, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	347233
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/09:00208621
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	indomethacin; non-steroidal anti-inflammatory drugs; gastrointestinal lesions; rat; macroscopy/microscopy (en)
http://linked.open.../riv/klicoveSlovo	indomethacin rat non-steroidal anti-inflammatory drugs gastrointestinal lesions macroscopy/microscopy
http://linked.open...odStatuVydavatele	SE - Švédské království
http://linked.open...ontrolniKodProRIV	[8AE5CC61EDC2]
http://linked.open...i/riv/nazevZdroje	Neuroendocrinology Letters
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Interference of probiotics with factors determining pharmacokinetics of drugs
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	30
http://linked.open...iv/tvurceVysledku	Bureš, Jan Kuneš, Martin Květina, Jaroslav
http://linked.open...ain/vavai/riv/wos	000275266600019
http://linked.open...n/vavai/riv/zamer	Nové diagnostické indikátory a léčebné postupy v závislosti na různých obdobích života s důrazem na stáří
issn	0172-780X
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	11150

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