About: Primary cutaneous anaplastic large cell lymphoma with angioinvasive features and cytotoxic phenotype: a rare lymphoma variant within the spectrum fo CD30+ lymphoproliferative disorders     Goto   Sponge   Distinct   Permalink

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Description
  • Background: Primary cutaneous anaplastic large cell lymphoma (PCALCL) presents with solitary or grouped exophytic tumors and cohesive infiltrates of large CD30+ T cells. Objective: To report an angioinvasive variant of PCALCL. Methods: Retrospective analysis of clinicopathological features of this variant. Results: The group consisted of six patients (median age 46 years) with a solitary flat necrotic lesion preferentially located on the upper extremity. Histologically, there were angiocentric and angiodestructive infiltrates of medium-sized to large pleomorphic and anaplastic cells co-expressing CD30 and CD8. Five patients were treated with surgical excision and one patient with radiotherapy. A relapse was observed in one patient with spontaneous regression of the lesions suggesting a link to the recently described angioinvasive lymphomatoid papulosis (type E). All patients were alive without evidence of disease after a median follow-up of 31 months (range 15-96), indicating an excellent prognosis. Conclusions: The angioinvasive variant of PCALCL is rare but distinctive and prone to misinterpretation as aggressive lymphoma due to its histological features.
  • Background: Primary cutaneous anaplastic large cell lymphoma (PCALCL) presents with solitary or grouped exophytic tumors and cohesive infiltrates of large CD30+ T cells. Objective: To report an angioinvasive variant of PCALCL. Methods: Retrospective analysis of clinicopathological features of this variant. Results: The group consisted of six patients (median age 46 years) with a solitary flat necrotic lesion preferentially located on the upper extremity. Histologically, there were angiocentric and angiodestructive infiltrates of medium-sized to large pleomorphic and anaplastic cells co-expressing CD30 and CD8. Five patients were treated with surgical excision and one patient with radiotherapy. A relapse was observed in one patient with spontaneous regression of the lesions suggesting a link to the recently described angioinvasive lymphomatoid papulosis (type E). All patients were alive without evidence of disease after a median follow-up of 31 months (range 15-96), indicating an excellent prognosis. Conclusions: The angioinvasive variant of PCALCL is rare but distinctive and prone to misinterpretation as aggressive lymphoma due to its histological features. (en)
Title
  • Primary cutaneous anaplastic large cell lymphoma with angioinvasive features and cytotoxic phenotype: a rare lymphoma variant within the spectrum fo CD30+ lymphoproliferative disorders
  • Primary cutaneous anaplastic large cell lymphoma with angioinvasive features and cytotoxic phenotype: a rare lymphoma variant within the spectrum fo CD30+ lymphoproliferative disorders (en)
skos:prefLabel
  • Primary cutaneous anaplastic large cell lymphoma with angioinvasive features and cytotoxic phenotype: a rare lymphoma variant within the spectrum fo CD30+ lymphoproliferative disorders
  • Primary cutaneous anaplastic large cell lymphoma with angioinvasive features and cytotoxic phenotype: a rare lymphoma variant within the spectrum fo CD30+ lymphoproliferative disorders (en)
skos:notation
  • RIV/00216208:11140/13:10188840!RIV14-MSM-11140___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 99291
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11140/13:10188840
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • lymphomatoid papulosis; CD30; angiocentric; cytotoxic lymphomas; anaplastic large cell lymphoma; cutaneous lymphoma (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV
  • [3B9DA8126FD8]
http://linked.open...i/riv/nazevZdroje
  • Dermatology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 227
http://linked.open...iv/tvurceVysledku
  • Kazakov, Dmitry
  • Kempf, Werner
  • Kutzner, Heinz
  • Palmedo, Gabriele
  • Laeng, Hubert
  • Paredes, Bruno
http://linked.open...ain/vavai/riv/wos
  • 000329443100010
issn
  • 1018-8665
number of pages
http://bibframe.org/vocab/doi
  • 10.1159/000355479
http://localhost/t...ganizacniJednotka
  • 11140
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