About: Switch from a dominant Th1-associated immune profile during the pre-diabetic phase in favour of a temporary increase of a Th3-associated and inflammatory immune profile at the onset of type 1 diabetes

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About: Switch from a dominant Th1-associated immune profile during the pre-diabetic phase in favour of a temporary increase of a Th3-associated and inflammatory immune profile at the onset of type 1 diabetes Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This study aims to confirm previous observations of a dominant T-helper (Th)1-like profile during the period close to onset of disease. Peripheral blood mononuclear cells were collected 4 days and 1 and 2 years after diagnosis of T1D children, from healthy children carrying the human leukocyte antigen-risk genes and from high-risk children (ICA >= 20 IJDF units). Peripheral blood mononuclear cells were stimulated by diabetes associated autoantigens and cytokines and chemokines were detected in cell-culture supernatants by protein microarray in relation to clinical outcome (C-peptide). High-risk children showed a dominant Th1-associated profile with high spontaneous and GAD(65)-induced secretion. In contrast, newly diagnosed T1D children showed a pronounced Th3-associated cytokine profile as well as a burst of inflammatory cytokines and chemokines. The Th1 dominance typical of prediabetes phase, however, diminished by the time of T1D diagnose. This study aims to confirm previous observations of a dominant T-helper (Th)1-like profile during the period close to onset of disease. Peripheral blood mononuclear cells were collected 4 days and 1 and 2 years after diagnosis of T1D children, from healthy children carrying the human leukocyte antigen-risk genes and from high-risk children (ICA >= 20 IJDF units). Peripheral blood mononuclear cells were stimulated by diabetes associated autoantigens and cytokines and chemokines were detected in cell-culture supernatants by protein microarray in relation to clinical outcome (C-peptide). High-risk children showed a dominant Th1-associated profile with high spontaneous and GAD(65)-induced secretion. In contrast, newly diagnosed T1D children showed a pronounced Th3-associated cytokine profile as well as a burst of inflammatory cytokines and chemokines. The Th1 dominance typical of prediabetes phase, however, diminished by the time of T1D diagnose. (en)
Title	Switch from a dominant Th1-associated immune profile during the pre-diabetic phase in favour of a temporary increase of a Th3-associated and inflammatory immune profile at the onset of type 1 diabetes Switch from a dominant Th1-associated immune profile during the pre-diabetic phase in favour of a temporary increase of a Th3-associated and inflammatory immune profile at the onset of type 1 diabetes (en)
skos:prefLabel	Switch from a dominant Th1-associated immune profile during the pre-diabetic phase in favour of a temporary increase of a Th3-associated and inflammatory immune profile at the onset of type 1 diabetes Switch from a dominant Th1-associated immune profile during the pre-diabetic phase in favour of a temporary increase of a Th3-associated and inflammatory immune profile at the onset of type 1 diabetes (en)
skos:notation	RIV/00216208:11130/09:5393!RIV10-MZ0-11130___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MZ0FNM2005)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Durilová, Marianna Štechová, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	344943
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/09:5393
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Type 1 diabetes; high-risk children; T-helper cells; T-regulatory cells; cytokines; chemokines; monocyte chemoattractant protein-1; glutamic-acid decarboxylase; chronic autoimmune-disease; blood mononuclear-cells; ifn-gamma; high-risk; nod mice; t-cells; cytokine production; regulatory-cells/ (en)
http://linked.open.../riv/klicoveSlovo	glutamic-acid decarboxylase T-regulatory cells high-risk t-cells T-helper cells Type 1 diabetes cytokines chemokines nod mice monocyte chemoattractant protein-1 cytokine production chronic autoimmune-disease high-risk children ifn-gamma regulatory-cells/ blood mononuclear-cells
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[001BA8A67F90]
http://linked.open...i/riv/nazevZdroje	Diabetes-Metabolism Research and Reviews
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	25
http://linked.open...iv/tvurceVysledku	Durilová, Marianna Štechová, Kateřina Faresjo, M. Ryden, A.
http://linked.open...ain/vavai/riv/wos	000266347200008
http://linked.open...n/vavai/riv/zamer	Zdokonalení časné diagnostiky, prevence a léčby těžkých vrozených vývojových vad a chorob geneticky podmíněných či s genetickou dispozicí v prenatální a postnatální fázi vývoje
issn	1520-7552
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	11130

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