About: Gender differences in behavioral changes elicited by prenatal methamphetamine exposure and application of the same drug in adulthood

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About: Gender differences in behavioral changes elicited by prenatal methamphetamine exposure and application of the same drug in adulthood Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of the present study was to compare the response to sub-chronic application of methamphetamine (MA) in adulthood in male and female rats prenatally exposed to the same drug. The spontaneous locomotor activity and exploratory behavior of adult male and female rats prenatally exposed to 5 mg/kg MA or saline (SAL) were tested in a Laboras apparatus (Metris B.V., Netherlands) for five consecutive days, 1 hr daily. MA 1 mg/kg or SAL were used as a challenge prior to testing. Our results showed that rats prenatally exposed to MA were more sensitive to sub-chronic administration of MA in adulthood than prenatally SAL-exposed rats. However, this sensitizing effect of prenatal MA exposure was manifested differently in males and females. In contrast, prenatal MA exposure decreased baseline locomotion in females. This study indicates that gender plays an important role in the sensitivity to MA during prenatal development and in adulthood The aim of the present study was to compare the response to sub-chronic application of methamphetamine (MA) in adulthood in male and female rats prenatally exposed to the same drug. The spontaneous locomotor activity and exploratory behavior of adult male and female rats prenatally exposed to 5 mg/kg MA or saline (SAL) were tested in a Laboras apparatus (Metris B.V., Netherlands) for five consecutive days, 1 hr daily. MA 1 mg/kg or SAL were used as a challenge prior to testing. Our results showed that rats prenatally exposed to MA were more sensitive to sub-chronic administration of MA in adulthood than prenatally SAL-exposed rats. However, this sensitizing effect of prenatal MA exposure was manifested differently in males and females. In contrast, prenatal MA exposure decreased baseline locomotion in females. This study indicates that gender plays an important role in the sensitivity to MA during prenatal development and in adulthood (en)
Title	Gender differences in behavioral changes elicited by prenatal methamphetamine exposure and application of the same drug in adulthood Gender differences in behavioral changes elicited by prenatal methamphetamine exposure and application of the same drug in adulthood (en)
skos:prefLabel	Gender differences in behavioral changes elicited by prenatal methamphetamine exposure and application of the same drug in adulthood Gender differences in behavioral changes elicited by prenatal methamphetamine exposure and application of the same drug in adulthood (en)
skos:notation	RIV/00216208:11120/13:43896925!RIV14-GA0-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/09/0126), P(NS10509), Z(MSM0021620816)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Schutová, Barbora Hrubá, Lenka Šlamberová, Romana Rokyta, Richard
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	76245
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/13:43896925
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	exploratory behavior; locomotion; Laboras; gender differences; prenatal exposure; methamphetamine (en)
http://linked.open.../riv/klicoveSlovo	exploratory behavior locomotion gender differences methamphetamine Laboras prenatal exposure
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[603279B6E2DB]
http://linked.open...i/riv/nazevZdroje	Developmental Psychobiology
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Does prenatal methamphetamine exposure induce cross-sensitization to drugs in adult male and female rats? Active drug-seeking behavior in prenatally methamphetamine-exposed adult male and female rats
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	55
http://linked.open...iv/tvurceVysledku	Hrubá, Lenka Rokyta, Richard Schutová, Barbora Šlamberová, Romana
http://linked.open...ain/vavai/riv/wos	000316464400003
http://linked.open...n/vavai/riv/zamer	Název: Patofyziologie neuropsychiatrických onemocnění a její klinické aplikace
issn	0012-1630
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/dev.21016
http://localhost/t...ganizacniJednotka	11120

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