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Description
| - One of the most robust genetic associations for cardiovascular disease (CVD) is the Chromosome 9p21 region. However, the interaction of this locus with environmental factors has not been extensively explored. We investigated the association of 9p21 with myocardial infarction (MI) in individuals of different ethnicities, and tested for an interaction with environmental factors. We genotyped four 9p21 SNPs in 8,114 individuals from the global INTERHEART study. All four variants were associated with MI, with odds ratios (ORs) of 1.18 to 1.20 (1.85 x 10(-8) <= p <= 5.21 x 10(-7)). A significant interaction (p = 4.0 x 10(-4)) was observed between rs2383206 and a factor-analysis-derived %22prudent%22 diet pattern score, for which a major component was raw vegetables. An effect of 9p21 on MI was observed in the group with a low prudent diet score (OR = 1.32, p = 6.82 x 10(-7)), but the effect was diminished in a step-wise fashion in the medium (OR = 1.17, p = 4.9 x 10(-3)) and high prudent diet s
- One of the most robust genetic associations for cardiovascular disease (CVD) is the Chromosome 9p21 region. However, the interaction of this locus with environmental factors has not been extensively explored. We investigated the association of 9p21 with myocardial infarction (MI) in individuals of different ethnicities, and tested for an interaction with environmental factors. We genotyped four 9p21 SNPs in 8,114 individuals from the global INTERHEART study. All four variants were associated with MI, with odds ratios (ORs) of 1.18 to 1.20 (1.85 x 10(-8) <= p <= 5.21 x 10(-7)). A significant interaction (p = 4.0 x 10(-4)) was observed between rs2383206 and a factor-analysis-derived %22prudent%22 diet pattern score, for which a major component was raw vegetables. An effect of 9p21 on MI was observed in the group with a low prudent diet score (OR = 1.32, p = 6.82 x 10(-7)), but the effect was diminished in a step-wise fashion in the medium (OR = 1.17, p = 4.9 x 10(-3)) and high prudent diet s (en)
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Title
| - The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study
- The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study (en)
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skos:prefLabel
| - The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study
- The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study (en)
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skos:notation
| - RIV/00216208:11120/11:00003516!RIV12-MSM-11120___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/11:00003516
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Coronary-Artery-Disease; Acute Myocardial-Infarction; Heart-Disease; Risk-Factors; Genomewide Association; 52 Countries; Life-Style (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Widimský, Petr
- Do, R.
- Gregor, Pavel
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1371/journal.pmed.1001106
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http://localhost/t...ganizacniJednotka
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