About: Impact of prenatal methamphetamine exposure on the sensitivity to the same drug in adult male rats

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	There are only few studies that examine the effect of prenatal methamphetamine (MA) exposure on the sensitivity to the same drug and the drug-seeking behavior in adulthood. The aim of the present study was to examine the effect of prenatal MA exposure on exploratory behavior and nociception with respect to challenge dose of the same drug. Mothers of the tested offspring received a daily injection of MA (5 mg/kg) or saline throughout the gestation period. Adult male offspring (prenatally MA- or saline-exposed) were divided to groups with challenge dose of MA (1 mg/kg) or saline. A modified Open field test (Laboras) was used to examine behavior in unknown environment. Plantar test was used to measure nociception on forelimbs, hind limbs, and the tail. Conditioned place preference (CPP) test was used to examine drug-seeking behavior. Our results in Laboras demonstrated that prenatal MA exposure sensitized the animals to the challenge dose of MA. There are only few studies that examine the effect of prenatal methamphetamine (MA) exposure on the sensitivity to the same drug and the drug-seeking behavior in adulthood. The aim of the present study was to examine the effect of prenatal MA exposure on exploratory behavior and nociception with respect to challenge dose of the same drug. Mothers of the tested offspring received a daily injection of MA (5 mg/kg) or saline throughout the gestation period. Adult male offspring (prenatally MA- or saline-exposed) were divided to groups with challenge dose of MA (1 mg/kg) or saline. A modified Open field test (Laboras) was used to examine behavior in unknown environment. Plantar test was used to measure nociception on forelimbs, hind limbs, and the tail. Conditioned place preference (CPP) test was used to examine drug-seeking behavior. Our results in Laboras demonstrated that prenatal MA exposure sensitized the animals to the challenge dose of MA. (en)
Title	Impact of prenatal methamphetamine exposure on the sensitivity to the same drug in adult male rats Impact of prenatal methamphetamine exposure on the sensitivity to the same drug in adult male rats (en)
skos:prefLabel	Impact of prenatal methamphetamine exposure on the sensitivity to the same drug in adult male rats Impact of prenatal methamphetamine exposure on the sensitivity to the same drug in adult male rats (en)
skos:notation	RIV/00216208:11120/11:00003174!RIV12-MZ0-11120___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA305/09/0126), P(GAP303/10/0580), P(NS10509)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Schutová, Barbora Pometlová, Marie Hrubá, Lenka Šlamberová, Romana Yamamotová, Anna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	203701
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/11:00003174
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	prenatal drug exposure; methamphetamine; Open field; Plantar test: Conditioned place preference; locomotion; nociception; drug-seeking behavior (en)
http://linked.open.../riv/klicoveSlovo	locomotion methamphetamine Open field Plantar test: Conditioned place preference drug-seeking behavior nociception prenatal drug exposure
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[5FCD997EDE5E]
http://linked.open...i/riv/nazevZdroje	Prague Medical Report
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Does prenatal methamphetamine exposure induce cross-sensitization to drugs in adult male and female rats? Active drug-seeking behavior in prenatally methamphetamine-exposed adult male and female rats What is the role of mesolimbic reward circuit in the long-term effect of prenatal methamphetamine exposure in rats?
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	112
http://linked.open...iv/tvurceVysledku	Hrubá, Lenka Pometlová, Marie Schutová, Barbora Šlamberová, Romana Yamamotová, Anna
issn	1214-6994
number of pages	13 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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