About: Influence of Low-Dose Neonatal Domoic Acid on the Spontaneous Behavior of Rats in Early Adulthood

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.biomed.cas.cz/physiolres/pdf/63/63_S521.pdf
Description	Consumption of seafood containing toxin domoic acid (DA) causes an alteration of glutamatergic signaling pathways and could lead to various signs of neurotoxicity in animals and humans. Neonatal treatment with domoic acid was suggested as valuable model of schizophrenia and epilepsy. We tested how repeated early postnatal DA administration influences the spontaneous behavior of rats in adulthood. Rats were injected with 30 mu g DA/kg from postnatal day (PND) 10 until PND 14. Their behavior was observed in the open field test for one hour (Laboras, Metris) at PND 35, PND 42 and PND 112. We did not find any difference between DA treated rats and animals injected with equivalent volume of saline in both test sessions at PND 35 and PND 42. DA rats at PND 112 exhibited significantly higher vertical and horizontal exploratory activity (tested parameters: locomotion, distance travelled, average speed reached during test, grooming and rearing) between the 30th-40th min of the test session and habituated over 10 min later. We conclude that at least in the given experimental design, neonatal DA treatment results in alteration of the spontaneous behavior of rats in adulthood. Consumption of seafood containing toxin domoic acid (DA) causes an alteration of glutamatergic signaling pathways and could lead to various signs of neurotoxicity in animals and humans. Neonatal treatment with domoic acid was suggested as valuable model of schizophrenia and epilepsy. We tested how repeated early postnatal DA administration influences the spontaneous behavior of rats in adulthood. Rats were injected with 30 mu g DA/kg from postnatal day (PND) 10 until PND 14. Their behavior was observed in the open field test for one hour (Laboras, Metris) at PND 35, PND 42 and PND 112. We did not find any difference between DA treated rats and animals injected with equivalent volume of saline in both test sessions at PND 35 and PND 42. DA rats at PND 112 exhibited significantly higher vertical and horizontal exploratory activity (tested parameters: locomotion, distance travelled, average speed reached during test, grooming and rearing) between the 30th-40th min of the test session and habituated over 10 min later. We conclude that at least in the given experimental design, neonatal DA treatment results in alteration of the spontaneous behavior of rats in adulthood. (en)
Title	Influence of Low-Dose Neonatal Domoic Acid on the Spontaneous Behavior of Rats in Early Adulthood Influence of Low-Dose Neonatal Domoic Acid on the Spontaneous Behavior of Rats in Early Adulthood (en)
skos:prefLabel	Influence of Low-Dose Neonatal Domoic Acid on the Spontaneous Behavior of Rats in Early Adulthood Influence of Low-Dose Neonatal Domoic Acid on the Spontaneous Behavior of Rats in Early Adulthood (en)
skos:notation	RIV/00216208:11110/14:10293966!RIV15-MSM-11110___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	Suppl. 4
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Riljak, Vladimír Marešová, Dana Kozler, Petr Pokorný, Jaroslav Jandová, Kateřina Langmeier, Miloš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	21493
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/14:10293966
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Rat; Open field test; Locomotor activity; Domoic acid (en)
http://linked.open.../riv/klicoveSlovo	Domoic acid Open field test Rat Locomotor activity
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[E2BBEBE1BAA0]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	63
http://linked.open...iv/tvurceVysledku	Pokorný, Jaroslav Marešová, Dana Riljak, Vladimír Kozler, Petr Jandová, Kateřina Langmeier, Miloš
http://linked.open...ain/vavai/riv/wos	000351014100009
issn	0862-8408
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11110

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