About: Late recovery of renal function by rituximab in a patient with Wegener's granulomatosis     Goto   Sponge   Distinct   Permalink

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  • Rituximab has proven effective in the treatment of complicated granulomatosis with polyangiitis (Wegener's, GPA). Two controlled trials in adults demonstrated beneficial effects of rituximab compared to cyclophosphamide in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis to induce remission and to treat relapses. Pediatric experience with rituximab in GPA is limited; the impact on renal function is unknown. We report a female adolescent with GPA and necrotizing glomerulonephritis that lead to end-stage renal disease (ESRD). After 22 months of peritoneal dialysis, she still experienced relapses and major treatment-associated adverse effects. After a single dose of rituximab, she rapidly achieved clinical remission and, unexpectedly, steadily recovered glomerular filtration rate, plateauing at 25 ml/min/1.73 m(2). Peritoneal dialysis could be discontinued for 16 months. This case documents a potent beneficial effect of rituximab on renal manifestation of GPA even in long-established ESRD.
  • Rituximab has proven effective in the treatment of complicated granulomatosis with polyangiitis (Wegener's, GPA). Two controlled trials in adults demonstrated beneficial effects of rituximab compared to cyclophosphamide in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis to induce remission and to treat relapses. Pediatric experience with rituximab in GPA is limited; the impact on renal function is unknown. We report a female adolescent with GPA and necrotizing glomerulonephritis that lead to end-stage renal disease (ESRD). After 22 months of peritoneal dialysis, she still experienced relapses and major treatment-associated adverse effects. After a single dose of rituximab, she rapidly achieved clinical remission and, unexpectedly, steadily recovered glomerular filtration rate, plateauing at 25 ml/min/1.73 m(2). Peritoneal dialysis could be discontinued for 16 months. This case documents a potent beneficial effect of rituximab on renal manifestation of GPA even in long-established ESRD. (en)
Title
  • Late recovery of renal function by rituximab in a patient with Wegener's granulomatosis
  • Late recovery of renal function by rituximab in a patient with Wegener's granulomatosis (en)
skos:prefLabel
  • Late recovery of renal function by rituximab in a patient with Wegener's granulomatosis
  • Late recovery of renal function by rituximab in a patient with Wegener's granulomatosis (en)
skos:notation
  • RIV/00064203:_____/13:10209785!RIV14-MZ0-00064203
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 84379
http://linked.open...ai/riv/idVysledku
  • RIV/00064203:_____/13:10209785
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • therapy; cyclophosphamide; clinical-features; anca-associated vasculitis (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [00E6D7D5DCA6]
http://linked.open...i/riv/nazevZdroje
  • Pediatric Nephrology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 28
http://linked.open...iv/tvurceVysledku
  • Malina, Michal
  • Schmitt, Claus Peter
  • Schaefer, Franz
  • Schaefer, Betti
  • Waldherr, Ruediger
  • Wuehl, Elke
http://linked.open...ain/vavai/riv/wos
  • 000314038000020
issn
  • 0931-041X
number of pages
http://bibframe.org/vocab/doi
  • 10.1007/s00467-012-2332-4
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