About: Cardiac Gap Junction Channels Are Upregulated by Metoprolol: An Unexpected Effect of Beta-Blockers

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The authors wanted to elucidate the possible effect of metoprolol on the gap junction protein. Cultured neonatal rat cardiomyocytes were exposed to either RS-metoprolol or R-metoprolol or S-metoprolol treatment for 24 hours without or with additional isoprenaline. The beta-blocker treatment did not alter frequency of spontaneously beating cardiomyocytes, vhereas sole isoprenaline administration significantly enhanced the beating frequency by about 40%. The authors wanted to elucidate the possible effect of metoprolol on the gap junction protein. Cultured neonatal rat cardiomyocytes were exposed to either RS-metoprolol or R-metoprolol or S-metoprolol treatment for 24 hours without or with additional isoprenaline. The beta-blocker treatment did not alter frequency of spontaneously beating cardiomyocytes, vhereas sole isoprenaline administration significantly enhanced the beating frequency by about 40%. (en)
Title	Cardiac Gap Junction Channels Are Upregulated by Metoprolol: An Unexpected Effect of Beta-Blockers Cardiac Gap Junction Channels Are Upregulated by Metoprolol: An Unexpected Effect of Beta-Blockers (en)
skos:prefLabel	Cardiac Gap Junction Channels Are Upregulated by Metoprolol: An Unexpected Effect of Beta-Blockers Cardiac Gap Junction Channels Are Upregulated by Metoprolol: An Unexpected Effect of Beta-Blockers (en)
skos:notation	RIV/00064203:_____/10:6584!RIV11-MZ0-00064203
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Janoušek, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice v Motole
http://linked.open...dnocenehoVysledku	249625
http://linked.open...ai/riv/idVysledku	RIV/00064203:_____/10:6584
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cx43; Cardiomyocytes; R-metoprolol; S-metoprolol; RS-metoprolol; ERK; cAMP (en)
http://linked.open.../riv/klicoveSlovo	cAMP ERK Cardiomyocytes Cx43 R-metoprolol RS-metoprolol S-metoprolol
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[E996D3059C23]
http://linked.open...i/riv/nazevZdroje	Pharmacology
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	85
http://linked.open...iv/tvurceVysledku	Janoušek, Jan Salemeh, Aida Blanke, Katja Dhein, Stefan
http://linked.open...ain/vavai/riv/wos	000277110500002
issn	0031-7012
number of pages	8 (xsd:int)

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