About: The signal transduction cascade regulating the expression of the gap junction protein connexin43 by beta-adrenoceptors

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About: The signal transduction cascade regulating the expression of the gap junction protein connexin43 by beta-adrenoceptors Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	BACKGROUND AND PURPOSE: In mammalian heart, connexin43 (Cx43) represents the predominant connexin in the working myocardium. As the beta-adrenoceptor is involved in many cardiac diseases, we wanted to clarify the pathway by which beta-adrenoceptor stimulation may control Cx43 expression. EXPERIMENTAL APPROACH: Cultured neonatal rat cardiomyocytes were stimulated with isoprenaline. Cx43 expression as well as activation of p38 mitogen-activated protein kinase (MAPK), p42/44 MAPK, JUN NH(2)-terminal kinase (JNK) and nuclear translocation of the transcription factors activator protein 1 (AP1) and CRE-binding protein (CREB) were investigated. Additionally, we assessed Cx43 expression and distribution in left ventricular biopsies from patients without any significant heart disease, and from patients with either congestive heart failure [dilated cardiomyopathy (DCM)] or hypertrophic cardiomyopathy (HCM). KEY RESULTS: Isoprenaline exposure caused about twofold up-regulation of Cx43 protein with a pEC(50) of 7 BACKGROUND AND PURPOSE: In mammalian heart, connexin43 (Cx43) represents the predominant connexin in the working myocardium. As the beta-adrenoceptor is involved in many cardiac diseases, we wanted to clarify the pathway by which beta-adrenoceptor stimulation may control Cx43 expression. EXPERIMENTAL APPROACH: Cultured neonatal rat cardiomyocytes were stimulated with isoprenaline. Cx43 expression as well as activation of p38 mitogen-activated protein kinase (MAPK), p42/44 MAPK, JUN NH(2)-terminal kinase (JNK) and nuclear translocation of the transcription factors activator protein 1 (AP1) and CRE-binding protein (CREB) were investigated. Additionally, we assessed Cx43 expression and distribution in left ventricular biopsies from patients without any significant heart disease, and from patients with either congestive heart failure [dilated cardiomyopathy (DCM)] or hypertrophic cardiomyopathy (HCM). KEY RESULTS: Isoprenaline exposure caused about twofold up-regulation of Cx43 protein with a pEC(50) of 7 (en)
Title	The signal transduction cascade regulating the expression of the gap junction protein connexin43 by beta-adrenoceptors The signal transduction cascade regulating the expression of the gap junction protein connexin43 by beta-adrenoceptors (en)
skos:prefLabel	The signal transduction cascade regulating the expression of the gap junction protein connexin43 by beta-adrenoceptors The signal transduction cascade regulating the expression of the gap junction protein connexin43 by beta-adrenoceptors (en)
skos:notation	RIV/00064203:_____/09:5985!RIV10-MZ0-00064203
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Janoušek, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice v Motole
http://linked.open...dnocenehoVysledku	341126
http://linked.open...ai/riv/idVysledku	RIV/00064203:_____/09:5985
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cx43; cardiomyocytes; beta-adrenoceptor; isoprenaline; MAPK; congestive heart failure; hypertrophic cardiomyopathy; human cardiac biopsy (en)
http://linked.open.../riv/klicoveSlovo	isoprenaline MAPK beta-adrenoceptor human cardiac biopsy cardiomyocytes congestive heart failure Cx43 hypertrophic cardiomyopathy
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[F1CC08EB5BDE]
http://linked.open...i/riv/nazevZdroje	British Journal of Pharmacology
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	158
http://linked.open...iv/tvurceVysledku	Janoušek, Jan Blanke, K. Dhein, S. Salameh, Aida Gomez, DR Karl, S. Krautblatter, S. Pfeiffer, D.
http://linked.open...ain/vavai/riv/wos	000269315700020
issn	0007-1188
number of pages	11 (xsd:int)

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