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Description
| - The aim of the study was to analyze menopausal changes in components of metabolic syndrome (MS) and the parameter of insulin resistance (HOMA-IR). A random population sample of 909 women aged 45–54 years was examined. RESULTS The prevalence of MS rose significantly in menopause (REPRO/POSTm 22.9+2.6% /38.3+4.0%; p<0.001). However, a detailed analysis showed among the five components defining MS that increases were only seen in waist circumference (p<0.0001) and triglycerides (p<0.001). A detailed analysis showed an increase in HOMA-IR at levels above the median (REPRO/POSTm: low HOMA-IR 0.9/0.9, ns; high HOMA-IR 1.8/2.1, p<0.001) and an increase in the prevalence of MS just in these high levels of HOMA-IR and those rising during menopause (REPRO/POSTm: low HOMAIR 13.8%/18.7%, ns; high HOMA-IR 30.9%/57.3%, p<0.0001). CONCLUSION The acceleration of MS prevalence at the onset of menopause may be accompanied by an increase in insulin resistance only in the population at highest risk.
- The aim of the study was to analyze menopausal changes in components of metabolic syndrome (MS) and the parameter of insulin resistance (HOMA-IR). A random population sample of 909 women aged 45–54 years was examined. RESULTS The prevalence of MS rose significantly in menopause (REPRO/POSTm 22.9+2.6% /38.3+4.0%; p<0.001). However, a detailed analysis showed among the five components defining MS that increases were only seen in waist circumference (p<0.0001) and triglycerides (p<0.001). A detailed analysis showed an increase in HOMA-IR at levels above the median (REPRO/POSTm: low HOMA-IR 0.9/0.9, ns; high HOMA-IR 1.8/2.1, p<0.001) and an increase in the prevalence of MS just in these high levels of HOMA-IR and those rising during menopause (REPRO/POSTm: low HOMAIR 13.8%/18.7%, ns; high HOMA-IR 30.9%/57.3%, p<0.0001). CONCLUSION The acceleration of MS prevalence at the onset of menopause may be accompanied by an increase in insulin resistance only in the population at highest risk. (en)
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Title
| - Menopause: Clustering of metabolic syndrome components and population changes of insulin resistance.
- Menopause: Clustering of metabolic syndrome components and population changes of insulin resistance. (en)
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skos:prefLabel
| - Menopause: Clustering of metabolic syndrome components and population changes of insulin resistance.
- Menopause: Clustering of metabolic syndrome components and population changes of insulin resistance. (en)
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skos:notation
| - RIV/00064190:_____/10:#0000025!RIV10-MZ0-00064190
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00064190:_____/10:#0000025
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - menopause; metabolic syndrome; central obesity; insulin resistance; cardiovascular disease; dyslipidemia; blood pressure (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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