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| rdf:type
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| Description
| - Cílem studie bylo charakterizovat vliv benzo(a)pyrenu (B(a)P) na vyvíjející se imunitní systém novorozených potkanů. Zvířata byla vystavena rozdílné koncentraci (0,1; 1,0 a 10,0 mg/kg/den) B(a)P v průběhu prvních 14 dní života a utracena 23.den experimentu Laboratorními analýzami bylo zjištěno, že klesající počet erytrocytů byl v přímé korelaci s dávkou B(a)P. U exponovaných zvířat také stoupal počet T lymfocytů a jejich mitogenní aktivita. Naopak produkce cytokinů IFN-gama a IL-4 měřená na úrovni mRNA byla nižší než u neexponovaných zvířat. Pokles poměru IFN-gama/IL-4 byl závislý na dávce B(a)P. Z těchto údajů se dá usoudit na to, že expozice novorozených mláďat účinku B(a)P může modulovat imunitní odpověď na infekci a/nebo vakcinaci. (cs)
- To determine the effect of benzo[a]pyrene (B[a]P) on the developing immune system of immature rats, newborn animals received different concentrations (0.1, 1.0 and 10.0 mg/kg/day) of B[a]P in the first 14 days after birth. These rats were euthanised on day 23 of the experiment and it was found that the decreasing numbers of erythrocytes were in direct correlation to the dose of B[a]P. In subject animals, the overall counts of T cells in the spleen and the mitogenic activity increased. A decrease in the production of both IFN-gama and IL-4 (measured at the mRNA level) as well as the decreasing IFN-gama/IL-4 ratio in rat splenocytes were dependent on the dose of B[a]P. From this we may deduce that exposure to B[a]P in immature animals may modulate the immune response to infection and/or vaccination.
- To determine the effect of benzo[a]pyrene (B[a]P) on the developing immune system of immature rats, newborn animals received different concentrations (0.1, 1.0 and 10.0 mg/kg/day) of B[a]P in the first 14 days after birth. These rats were euthanised on day 23 of the experiment and it was found that the decreasing numbers of erythrocytes were in direct correlation to the dose of B[a]P. In subject animals, the overall counts of T cells in the spleen and the mitogenic activity increased. A decrease in the production of both IFN-gama and IL-4 (measured at the mRNA level) as well as the decreasing IFN-gama/IL-4 ratio in rat splenocytes were dependent on the dose of B[a]P. From this we may deduce that exposure to B[a]P in immature animals may modulate the immune response to infection and/or vaccination. (en)
|
| Title
| - Effects of postnatal exposure to benzo[a]pyrene on the immunity of immature rats
- Vliv postnatální expozice účinku benzo[a]pyrenu na imunitu novorozených potkanů (cs)
- Effects of postnatal exposure to benzo[a]pyrene on the immunity of immature rats (en)
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| skos:prefLabel
| - Effects of postnatal exposure to benzo[a]pyrene on the immunity of immature rats
- Vliv postnatální expozice účinku benzo[a]pyrenu na imunitu novorozených potkanů (cs)
- Effects of postnatal exposure to benzo[a]pyrene on the immunity of immature rats (en)
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| skos:notation
| - RIV/00027162:_____/08:#0000333!RIV09-MZE-00027162
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA525/05/2695), Z(MZE0002716201)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00027162:_____/08:#0000333
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - polycyclic aromatic hydrocarbons; immunity; IFN-gama; IL-4; cytokines (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Faldyna, Martin
- Levá, Lenka
- Matiašovic, Ján
- Kummer, Vladimír
- Mašková, Jarmila
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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