About: Ubiquitin is associated with early truncation of tau protein at aspartic acid421 during the maturation of neurofibrillary tangles in Alzheimer´s disease

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About: Ubiquitin is associated with early truncation of tau protein at aspartic acid421 during the maturation of neurofibrillary tangles in Alzheimer´s disease Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1111/j.1750-3639.2011.00525.x
Description	Patological processing of tau protein during the formation and maturation of neurofibrillary tangles includes abnormal phosphorylation, conformational changes and truncation of the C-terminus. Abnormal phosphorylation and misfolding may serve as recognition signals for ubiquitin-targeting and proteosomal processing. Our findings indicate that tau protein in tangles may be dually subjected to both apoptotic and proteosomal processing. However, it appears that ubiquitin targeting of tau protein occurs at tangles in the early and intermediate stages of the maturation. Patological processing of tau protein during the formation and maturation of neurofibrillary tangles includes abnormal phosphorylation, conformational changes and truncation of the C-terminus. Abnormal phosphorylation and misfolding may serve as recognition signals for ubiquitin-targeting and proteosomal processing. Our findings indicate that tau protein in tangles may be dually subjected to both apoptotic and proteosomal processing. However, it appears that ubiquitin targeting of tau protein occurs at tangles in the early and intermediate stages of the maturation. (en)
Title	Ubiquitin is associated with early truncation of tau protein at aspartic acid421 during the maturation of neurofibrillary tangles in Alzheimer´s disease Ubiquitin is associated with early truncation of tau protein at aspartic acid421 during the maturation of neurofibrillary tangles in Alzheimer´s disease (en)
skos:prefLabel	Ubiquitin is associated with early truncation of tau protein at aspartic acid421 during the maturation of neurofibrillary tangles in Alzheimer´s disease Ubiquitin is associated with early truncation of tau protein at aspartic acid421 during the maturation of neurofibrillary tangles in Alzheimer´s disease (en)
skos:notation	RIV/00023752:_____/12:43913810!RIV13-MZ0-00023752
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MZ0PCP2005)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Řípová, Daniela Krištofiková, Zdena Garcia-Sierra, Francisco Basulto, José Jaime Jarero
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	175587
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/12:43913810
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Alzheimer´s disease; truncation; protein tau (en)
http://linked.open.../riv/klicoveSlovo	truncation protein tau Alzheimer´s disease
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[6BAD779232A0]
http://linked.open...i/riv/nazevZdroje	Brain Pathology
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	22
http://linked.open...iv/tvurceVysledku	Řípová, Daniela Krištofiková, Zdena Garcia-Sierra, Francisco Basulto, José Jaime Jarero Binder, Lester I. Majer, Emerich
http://linked.open...ain/vavai/riv/wos	000300834300010
http://linked.open...n/vavai/riv/zamer	Study of Sources f Psychiatric Morbidity , and Increasing the Effec-tiveness of the Preventative and Therapeutical methods in mental Health Care in the Czech Republic 2005?2011
issn	1015-6305
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1750-3639.2011.00525.x

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