About: The influence of polymorphism for gene RGS4 (Regulator of G-protein Signaling 4) on regional brain metabolism (18FDG PET) and phenotypic variables in schizophrenia

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About: The influence of polymorphism for gene RGS4 (Regulator of G-protein Signaling 4) on regional brain metabolism (18FDG PET) and phenotypic variables in schizophrenia Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	RGS4 represents a positional and functional candidate gene for schizophrenia confirmed by several studies in independent samples. In a group of 63 patients with schizophrenia, we have genotyped four SNPs (1,4,7,18)which have previously been associated with schizophrenia, individually or as part of haplotype. We evaluated the influence of candidate SNPs on phenotypic characteristics and regional brain metabolism measured by 18FDG PET. Neuroimaging data were treated by SPM99. We found lower metabolism bilaterally in basal ganglia (p<=0.05, corrected) in the risky G-allele carriers in SNP 7. In SNP 1, the trend for lower metabolism associated with the G-allele in the right prefrontal cortex was detected (p<=0.001). The risky G-allele was connected with lower expression of negative symptoms (SNP7) and later onset of schizophrenia (SNP 7,18).Our results support the role of basal ganglia and the prefrontal cortex in the mechanism of how the RGS4 polymorphism influrences schizophrenia. We formulate th RGS4 represents a positional and functional candidate gene for schizophrenia confirmed by several studies in independent samples. In a group of 63 patients with schizophrenia, we have genotyped four SNPs (1,4,7,18)which have previously been associated with schizophrenia, individually or as part of haplotype. We evaluated the influence of candidate SNPs on phenotypic characteristics and regional brain metabolism measured by 18FDG PET. Neuroimaging data were treated by SPM99. We found lower metabolism bilaterally in basal ganglia (p<=0.05, corrected) in the risky G-allele carriers in SNP 7. In SNP 1, the trend for lower metabolism associated with the G-allele in the right prefrontal cortex was detected (p<=0.001). The risky G-allele was connected with lower expression of negative symptoms (SNP7) and later onset of schizophrenia (SNP 7,18).Our results support the role of basal ganglia and the prefrontal cortex in the mechanism of how the RGS4 polymorphism influrences schizophrenia. We formulate th (en)
Title	The influence of polymorphism for gene RGS4 (Regulator of G-protein Signaling 4) on regional brain metabolism (18FDG PET) and phenotypic variables in schizophrenia The influence of polymorphism for gene RGS4 (Regulator of G-protein Signaling 4) on regional brain metabolism (18FDG PET) and phenotypic variables in schizophrenia (en)
skos:prefLabel	The influence of polymorphism for gene RGS4 (Regulator of G-protein Signaling 4) on regional brain metabolism (18FDG PET) and phenotypic variables in schizophrenia The influence of polymorphism for gene RGS4 (Regulator of G-protein Signaling 4) on regional brain metabolism (18FDG PET) and phenotypic variables in schizophrenia (en)
skos:notation	RIV/00023752:_____/09:00000960!RIV10-MZ0-00023752
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR9324)
http://linked.open...iv/cisloPeriodika	Suppl. 3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Höschl, Cyril Brunovský, Martin Horáček, Jiří Páleníček, Tomáš Vrajová, Monika Bubeníková-Valešová, Věra Mohr, Pavel Novák, Tomáš Španiel, Filip
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	319315
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/09:00000960
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	RGS4; schizophrenia; phenotypes; metabolism; 18FDG PET (en)
http://linked.open.../riv/klicoveSlovo	phenotypes 18FDG PET metabolism schizophrenia RGS4
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[03243796A4DC]
http://linked.open...i/riv/nazevZdroje	Psychiatrie
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	The candidate genes for schizophrenia: the influence on phenotypic variability in patients and in vitro manipulation of gene expression by the use of siRNA.
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	13
http://linked.open...iv/tvurceVysledku	Brunovský, Martin Horáček, Jiří Höschl, Cyril Minárik, Marek Mohr, Pavel Novák, Tomáš Páleníček, Tomáš Bubeníková-Valešová, Věra Vrajová, Monika Španiel, Filip
issn	1211-7579
number of pages	5 (xsd:int)

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