About: The influence of polymorphism for gene RGS4 (Regulator of G-protein Signaling 4) on regional brain metabolism (18FDG PET) and phenotypic variables in schizophrenia     Goto   Sponge   Distinct   Permalink

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  • RGS4 represents a positional and functional candidate gene for schizophrenia confirmed by several studies in independent samples. In a group of 63 patients with schizophrenia, we have genotyped four SNPs (1,4,7,18)which have previously been associated with schizophrenia, individually or as part of haplotype. We evaluated the influence of candidate SNPs on phenotypic characteristics and regional brain metabolism measured by 18FDG PET. Neuroimaging data were treated by SPM99. We found lower metabolism bilaterally in basal ganglia (p<=0.05, corrected) in the risky G-allele carriers in SNP 7. In SNP 1, the trend for lower metabolism associated with the G-allele in the right prefrontal cortex was detected (p<=0.001). The risky G-allele was connected with lower expression of negative symptoms (SNP7) and later onset of schizophrenia (SNP 7,18).Our results support the role of basal ganglia and the prefrontal cortex in the mechanism of how the RGS4 polymorphism influrences schizophrenia. We formulate th
  • RGS4 represents a positional and functional candidate gene for schizophrenia confirmed by several studies in independent samples. In a group of 63 patients with schizophrenia, we have genotyped four SNPs (1,4,7,18)which have previously been associated with schizophrenia, individually or as part of haplotype. We evaluated the influence of candidate SNPs on phenotypic characteristics and regional brain metabolism measured by 18FDG PET. Neuroimaging data were treated by SPM99. We found lower metabolism bilaterally in basal ganglia (p<=0.05, corrected) in the risky G-allele carriers in SNP 7. In SNP 1, the trend for lower metabolism associated with the G-allele in the right prefrontal cortex was detected (p<=0.001). The risky G-allele was connected with lower expression of negative symptoms (SNP7) and later onset of schizophrenia (SNP 7,18).Our results support the role of basal ganglia and the prefrontal cortex in the mechanism of how the RGS4 polymorphism influrences schizophrenia. We formulate th (en)
Title
  • The influence of polymorphism for gene RGS4 (Regulator of G-protein Signaling 4) on regional brain metabolism (18FDG PET) and phenotypic variables in schizophrenia
  • The influence of polymorphism for gene RGS4 (Regulator of G-protein Signaling 4) on regional brain metabolism (18FDG PET) and phenotypic variables in schizophrenia (en)
skos:prefLabel
  • The influence of polymorphism for gene RGS4 (Regulator of G-protein Signaling 4) on regional brain metabolism (18FDG PET) and phenotypic variables in schizophrenia
  • The influence of polymorphism for gene RGS4 (Regulator of G-protein Signaling 4) on regional brain metabolism (18FDG PET) and phenotypic variables in schizophrenia (en)
skos:notation
  • RIV/00023752:_____/09:00000960!RIV10-MZ0-00023752
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  • RIV/00023752:_____/09:00000960
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  • RGS4; schizophrenia; phenotypes; metabolism; 18FDG PET (en)
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  • CZ - Česká republika
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  • [03243796A4DC]
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  • Psychiatrie
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  • 13
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  • Brunovský, Martin
  • Horáček, Jiří
  • Höschl, Cyril
  • Minárik, Marek
  • Mohr, Pavel
  • Novák, Tomáš
  • Páleníček, Tomáš
  • Bubeníková-Valešová, Věra
  • Vrajová, Monika
  • Španiel, Filip
issn
  • 1211-7579
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