About: Combination of voxel based morphometry and diffusion tensor imaging in patients with Alzheimer`s disease

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	OBJECTIVE: The aim of the study was to assess structural changes in gray matter (GM) volume and fractional anisotropy (FA) in patients with Alzheimer`s disease (AD) compared to control subjects using Voxel-Based Morphometry (VBM). Fractional anisotropy in the corpus callosum of both groups was also calculated using ROI analysis. METHODS: Twenty-one patients and twenty-three control subjects underwent MRI examination using T1-weighted 3D MPRAGE sequence and diffusion spin-echo echo-planar imaging sequence in six directions. Structural MRI analyses for GM volume and FA were performed using an optimized VBM protocol implemented in SPM5. The influence of age and Mini-Mental State Examination (MMSE) was dealt with multiple regression analysis either for the whole group or for AD patients and controls separately. RESULTS: Patients showed significant reduction of GM volume mainly in the temporal lobes. In AD patients, no correlation was observed between GM volume and age or MMSE. FA was reduced in AD patient OBJECTIVE: The aim of the study was to assess structural changes in gray matter (GM) volume and fractional anisotropy (FA) in patients with Alzheimer`s disease (AD) compared to control subjects using Voxel-Based Morphometry (VBM). Fractional anisotropy in the corpus callosum of both groups was also calculated using ROI analysis. METHODS: Twenty-one patients and twenty-three control subjects underwent MRI examination using T1-weighted 3D MPRAGE sequence and diffusion spin-echo echo-planar imaging sequence in six directions. Structural MRI analyses for GM volume and FA were performed using an optimized VBM protocol implemented in SPM5. The influence of age and Mini-Mental State Examination (MMSE) was dealt with multiple regression analysis either for the whole group or for AD patients and controls separately. RESULTS: Patients showed significant reduction of GM volume mainly in the temporal lobes. In AD patients, no correlation was observed between GM volume and age or MMSE. FA was reduced in AD patient (en)
Title	Combination of voxel based morphometry and diffusion tensor imaging in patients with Alzheimer`s disease Combination of voxel based morphometry and diffusion tensor imaging in patients with Alzheimer`s disease (en)
skos:prefLabel	Combination of voxel based morphometry and diffusion tensor imaging in patients with Alzheimer`s disease Combination of voxel based morphometry and diffusion tensor imaging in patients with Alzheimer`s disease (en)
skos:notation	RIV/00023752:_____/09:00000942!RIV10-MZ0-00023752
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(1A8600), P(1M0517), P(NR8792), S, Z(MZ0IKEM2005), Z(MZ0PCP2005)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Brunovský, Martin Horáček, Jiří Řípová, Daniela Bartoš, Aleš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	307534
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/09:00000942
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Alzheimer`s disease; voxel-based morphometry; diffusion tensor imaging; MRI; white matter; grey matter; fractional anisotropy; age (en)
http://linked.open.../riv/klicoveSlovo	diffusion tensor imaging grey matter Alzheimer`s disease MRI age voxel-based morphometry white matter fractional anisotropy
http://linked.open...odStatuVydavatele	SE - Švédské království
http://linked.open...ontrolniKodProRIV	[0A6A6A888546]
http://linked.open...i/riv/nazevZdroje	Neuroendocrinology Letters
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Modern neurophysiological methods for diagnostics and follow-up examinations in dementia Glutamatergic theory of schizophrenia in animal and human models of disconnection tested by comparison with a population of schizophrenic patients Center of Neuropsychiatric Studies 2005-2009 (Neurobiology in Clinical Application)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	30
http://linked.open...iv/tvurceVysledku	Bartoš, Aleš Brunovský, Martin Horáček, Jiří Řípová, Daniela Hájek, M. Tintěra, Jaroslav Ibrahim, I.
http://linked.open...ain/vavai/riv/wos	000265426800011
http://linked.open...n/vavai/riv/zamer	Výzkum kardiovaskulárních nemocí, diabetu a transplantace životně důležitých orgánů Study of Sources f Psychiatric Morbidity , and Increasing the Effec-tiveness of the Preventative and Therapeutical methods in mental Health Care in the Czech Republic 2005?2011
issn	0172-780X
number of pages	7 (xsd:int)

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