About: Subgenual cingulate volumes in affected and unaffected offspring of bipolar parents

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background: Bipolar disorders (BD) have a strong genetic underpinning, yet no biological vulnerability markers for BD have been identified. Decreased volumes of subgenual cingulate (SGC) were replicated in familial bipolar patients. Presence of abnormality in unaffected subjects at genetic risk for an illness needs to be established before SGC volumes can be used as an endophenotype. This is the first study of SGC volumes in affected and unaffected subjects at familial risk for mood disorders. Method: High-risk participants were recruited from families multiply affected with BD. The high-risk sample included 13 affected and 13 unaffected offspring of bipolar I parents, who were matched by age and sex with 31 controls without a personal or family history of psychiatric disorders. The expanded sample consisted of 24 unaffected, 19 affected subjects all with a first or second degree relative suffering from BD I or II. The age range for all subjects was 15?30 years. Subgenual cingulate volumes were measur Background: Bipolar disorders (BD) have a strong genetic underpinning, yet no biological vulnerability markers for BD have been identified. Decreased volumes of subgenual cingulate (SGC) were replicated in familial bipolar patients. Presence of abnormality in unaffected subjects at genetic risk for an illness needs to be established before SGC volumes can be used as an endophenotype. This is the first study of SGC volumes in affected and unaffected subjects at familial risk for mood disorders. Method: High-risk participants were recruited from families multiply affected with BD. The high-risk sample included 13 affected and 13 unaffected offspring of bipolar I parents, who were matched by age and sex with 31 controls without a personal or family history of psychiatric disorders. The expanded sample consisted of 24 unaffected, 19 affected subjects all with a first or second degree relative suffering from BD I or II. The age range for all subjects was 15?30 years. Subgenual cingulate volumes were measur (en)
Title	Subgenual cingulate volumes in affected and unaffected offspring of bipolar parents Subgenual cingulate volumes in affected and unaffected offspring of bipolar parents (en)
skos:prefLabel	Subgenual cingulate volumes in affected and unaffected offspring of bipolar parents Subgenual cingulate volumes in affected and unaffected offspring of bipolar parents (en)
skos:notation	RIV/00023752:_____/08:00000785!RIV10-MZ0-00023752
http://linked.open...avai/riv/aktivita	S V
http://linked.open...avai/riv/aktivity	S, V
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hájek, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	398236
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/08:00000785
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	bipolar disorders; MRI; subgenual cingulate; high-risk (en)
http://linked.open.../riv/klicoveSlovo	high-risk MRI bipolar disorders subgenual cingulate
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[61092E37D5A5]
http://linked.open...i/riv/nazevZdroje	Journal of Affective Disorders
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	108
http://linked.open...iv/tvurceVysledku	Hájek, Tomáš Alda, M. Duffy, A. Grof, P. Propper, Lukáš Gunde, E. Bernier, D. MacQueen, G. Slaney, C.
http://linked.open...ain/vavai/riv/wos	000256769600009
issn	0165-0327
number of pages	7 (xsd:int)

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