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| Description
| - Dizocilpine (MK-801; 0,3 mg/kg i.p.) - induced disruption in prepulse inhibition of the acoustic startle response (PPI) can be preferentially restored by %22atypical%22 antipsychotics. In contrast, some finding indicate that not all of the %22atypical%22 antipsychotics, such as clozapine and risperidone, are effective in restoring the NMDA antagonist-induced deficits in PPI. In our study, we evaluated the effect of four different %22atypical%22 antipsychotic drugs on deficits in PPI induced by MK-801. Zotepine and risperidone have high affinities to D2-like and 5-HT2A receptors, while clozapine and olanzapine have multipharmacological profiles with the highest affinities to serotonin 5-HT1A,2A/2C receptors and muscarinic receptors. Results have shown that MK-801 disrupted PPI and increased the ASR in rats. Our results showed no effect of zotepine (1 and 2 mg/kg) and risperidone (0,1 and 1 mg/kg) on disrupted PPI by MK-801. Administration of clozapine (5 and 10 mg/kg) and olanzapine
- Dizocilpine (MK-801; 0,3 mg/kg i.p.) - induced disruption in prepulse inhibition of the acoustic startle response (PPI) can be preferentially restored by %22atypical%22 antipsychotics. In contrast, some finding indicate that not all of the %22atypical%22 antipsychotics, such as clozapine and risperidone, are effective in restoring the NMDA antagonist-induced deficits in PPI. In our study, we evaluated the effect of four different %22atypical%22 antipsychotic drugs on deficits in PPI induced by MK-801. Zotepine and risperidone have high affinities to D2-like and 5-HT2A receptors, while clozapine and olanzapine have multipharmacological profiles with the highest affinities to serotonin 5-HT1A,2A/2C receptors and muscarinic receptors. Results have shown that MK-801 disrupted PPI and increased the ASR in rats. Our results showed no effect of zotepine (1 and 2 mg/kg) and risperidone (0,1 and 1 mg/kg) on disrupted PPI by MK-801. Administration of clozapine (5 and 10 mg/kg) and olanzapine (en)
- Aplikace dizocilpinu (MK-801;0,3 mg/kg i.p.) poškozuje prepulzní inhibici akustické úlekové reakce (PPI). Deficit PPI navozený MK-801 je přednostně obnoven %22atypickými%22 antipsychotiky. Avšak některé nálezy ukazují, že ne všechna %22atypická%22 antipsychotika, jako je clozapin a risperidon jsou účinný v obnovení PPI. V naší studii jsme vyhodnotili účinek čtyř rozdílných %22atypických%22 antipsychotik na deficit v PPI navozený aplikací MK-801. Zotepin a risperidon vykazují vysokou afinitu k D2-like a 5-HT2A receptorům, ačkoliv clozapin a olanzapin mají multifarmakologický profil s vysokou afinitou k serotoninovým 5-HT1A a 5-HT2A/2C receptorům a muskarinovým receptorům. Výsledky ukazují, že MK-801 poškozuje PPI a zvyšuje úlekovou reakci u potkanů. Nebyl pozorován žádný efekt zotepinu (1 a 2 mg/kg) a risperidonu (0,1 a 1 mg/kg) na deficit v PPI navozený MK-801. Podání clozapinu (5 a 10 mg/kg) a olanzapinu (2,5 a 5 mg/kg) obnovilo PPI poškozené MK-801. Podání clozapinu v dávce 5 mg/kg (cs)
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| Title
| - The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating
- The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating (en)
- The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating (cs)
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| skos:prefLabel
| - The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating
- The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating (en)
- The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating (cs)
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| skos:notation
| - RIV/00023752:_____/05:00000476!RIV06-MZ0-00023752
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00023752:_____/05:00000476
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - antipsychotics; prepulse inhiibiton of the startle response; rats; MK-801 (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Pharmacology Biochemistry and Behavior
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Horáček, Jiří
- Páleníček, Tomáš
- Bubeníková, Věra
- Votava, M.
- Dockery, Colleen Anne
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| issn
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| number of pages
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