About: Hepcidin bound to alpha(2)-macroglobulin reduces ferroportin-1 expression and enhances its activity at reducing serum iron levels     Goto   Sponge   Distinct   Permalink

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Description
  • Hepcidin is the hormone of iron metabolism that is bound by alpha2-macroglobulin (alpha2M) and its activated counterpart (alpha2M-MA). Serum iron is reduced to a greater extent in mice treated with alpha2Mhepcidin or alpha2M-MAhepcidin relative to unbound hepcidin. Alpha2M retards hepcidin excretion by the kidney, increasing its efficacy. These results are important for understanding hepcidin transport and detection in blood.
  • Hepcidin is the hormone of iron metabolism that is bound by alpha2-macroglobulin (alpha2M) and its activated counterpart (alpha2M-MA). Serum iron is reduced to a greater extent in mice treated with alpha2Mhepcidin or alpha2M-MAhepcidin relative to unbound hepcidin. Alpha2M retards hepcidin excretion by the kidney, increasing its efficacy. These results are important for understanding hepcidin transport and detection in blood. (en)
Title
  • Hepcidin bound to alpha(2)-macroglobulin reduces ferroportin-1 expression and enhances its activity at reducing serum iron levels
  • Hepcidin bound to alpha(2)-macroglobulin reduces ferroportin-1 expression and enhances its activity at reducing serum iron levels (en)
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  • Hepcidin bound to alpha(2)-macroglobulin reduces ferroportin-1 expression and enhances its activity at reducing serum iron levels
  • Hepcidin bound to alpha(2)-macroglobulin reduces ferroportin-1 expression and enhances its activity at reducing serum iron levels (en)
skos:notation
  • RIV/00023736:_____/13:00010741!RIV14-MZ0-00023736
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  • I
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  • 35
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  • 77225
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  • RIV/00023736:_____/13:00010741
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  • hepcidin; iron metabolism; alpha-2-macroglobulin (en)
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  • US - Spojené státy americké
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  • [882F9DE87B42]
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  • Journal of biological chemistry
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  • 288
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  • Vyoral, Daniel
  • Austin, C.J.D.
  • Huang, M.L.H.
  • Poňka, P.
  • Rahmanto, Y. S.
  • Richardson, D.
  • Sari, M.-A.
http://linked.open...ain/vavai/riv/wos
  • 000330619000041
issn
  • 0021-9258
number of pages
http://bibframe.org/vocab/doi
  • 10.1074/jbc.M113.471573
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