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Description
| - As it is generally known, the heterochromatin is an useful marker of the cell maturity including its pathology. The goal of the study was to provide more information on the heterochromatin DNA state in chromosomes and central gene rich nuclear regions of single proliferating progenitors of human leukemic granulocytes. The computer image densitometry at the single cell level indicated that heterochromatin fibrils of similar width in the central nuclear regions are characterized by a similar DNA heterochromatin condensation state. Thus the DNA segments in heterochromatin fibrils represent masked chromosomal segments, which possibly carry silent genes. This observation is in harmony with the „classical cytology“ according to which such chromatin regions correspond to the chromosomal territories.
- As it is generally known, the heterochromatin is an useful marker of the cell maturity including its pathology. The goal of the study was to provide more information on the heterochromatin DNA state in chromosomes and central gene rich nuclear regions of single proliferating progenitors of human leukemic granulocytes. The computer image densitometry at the single cell level indicated that heterochromatin fibrils of similar width in the central nuclear regions are characterized by a similar DNA heterochromatin condensation state. Thus the DNA segments in heterochromatin fibrils represent masked chromosomal segments, which possibly carry silent genes. This observation is in harmony with the „classical cytology“ according to which such chromatin regions correspond to the chromosomal territories. (en)
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Title
| - The DNA chromatin condensation expressed by the image optical density of chromosomes and chromatin in proliferating single human leukemic granulocytic progenitors
- The DNA chromatin condensation expressed by the image optical density of chromosomes and chromatin in proliferating single human leukemic granulocytic progenitors (en)
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skos:prefLabel
| - The DNA chromatin condensation expressed by the image optical density of chromosomes and chromatin in proliferating single human leukemic granulocytic progenitors
- The DNA chromatin condensation expressed by the image optical density of chromosomes and chromatin in proliferating single human leukemic granulocytic progenitors (en)
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skos:notation
| - RIV/00023736:_____/12:00010472!RIV13-MZ0-00023736
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00023736:_____/12:00010472
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - heterochromatin image optical density; chromosomes; central and peripheral nuclear regions; proliferating cells-human leukemic myeloblasts (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of applied biomedicine
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Hrkal, Zbyněk
- Klamová, Hana
- Smetana, Karel
- Mikulenková, Dana
- Jirásková, Ilona
- Zápotocký, M.
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.2478/v10136-011-0005-4
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