About: The role of telomeres and telomerase complex in haematological neoplasia : the length of telomeres as a marker of carcinogenesis and prognosis of disease

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About: The role of telomeres and telomerase complex in haematological neoplasia : the length of telomeres as a marker of carcinogenesis and prognosis of disease Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Genetic instability associated with telomere dysfunction (i.e. short telomeres) is an early event in carcinogenesis. The molecular cytogenetic method telomere/centromere fluorescence in situ hybridization (T/C-FISH) can be used to characterize the telomere length of hematopoietic cells. This review describes recent advances in the molecular characterization of telomere system, the regulation of telomerase activity in cancer pathogenesis and shows that the telomeric length could be a potential clinical marker of hematologic neoplasia and prognosis of disease. Genetic instability associated with telomere dysfunction (i.e. short telomeres) is an early event in carcinogenesis. The molecular cytogenetic method telomere/centromere fluorescence in situ hybridization (T/C-FISH) can be used to characterize the telomere length of hematopoietic cells. This review describes recent advances in the molecular characterization of telomere system, the regulation of telomerase activity in cancer pathogenesis and shows that the telomeric length could be a potential clinical marker of hematologic neoplasia and prognosis of disease. (en)
Title	The role of telomeres and telomerase complex in haematological neoplasia : the length of telomeres as a marker of carcinogenesis and prognosis of disease The role of telomeres and telomerase complex in haematological neoplasia : the length of telomeres as a marker of carcinogenesis and prognosis of disease (en)
skos:prefLabel	The role of telomeres and telomerase complex in haematological neoplasia : the length of telomeres as a marker of carcinogenesis and prognosis of disease The role of telomeres and telomerase complex in haematological neoplasia : the length of telomeres as a marker of carcinogenesis and prognosis of disease (en)
skos:notation	RIV/00023736:_____/10:00008343!RIV11-MZ0-00023736
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(LC535), V, Z(MSM0021620808), Z(MZ0VFN2005)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Včelíková, Soňa Březinová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	285756
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/10:00008343
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	telomere; telomerase; leukemia; senescence (en)
http://linked.open.../riv/klicoveSlovo	telomerase leukemia senescence telomere
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[1116A2BBC85F]
http://linked.open...i/riv/nazevZdroje	Prague Medical Report
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Chromosome dynamics and organization during the cell cycle in normal and pathologic conditions
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	111
http://linked.open...iv/tvurceVysledku	Březinová, Jana Zemanová, Z. Michalová, K. Včelíková, Soňa Gančarčíková, M. Šmigová, J.
http://linked.open...n/vavai/riv/zamer	Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu Diagnosis and treatment of inherited disorders II
issn	1214-6994
number of pages	15 (xsd:int)

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