About: The role of telomeres and telomerase complex in haematological neoplasia : the length of telomeres as a marker of carcinogenesis and prognosis of disease     Goto   Sponge   Distinct   Permalink

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  • Genetic instability associated with telomere dysfunction (i.e. short telomeres) is an early event in carcinogenesis. The molecular cytogenetic method telomere/centromere fluorescence in situ hybridization (T/C-FISH) can be used to characterize the telomere length of hematopoietic cells. This review describes recent advances in the molecular characterization of telomere system, the regulation of telomerase activity in cancer pathogenesis and shows that the telomeric length could be a potential clinical marker of hematologic neoplasia and prognosis of disease.
  • Genetic instability associated with telomere dysfunction (i.e. short telomeres) is an early event in carcinogenesis. The molecular cytogenetic method telomere/centromere fluorescence in situ hybridization (T/C-FISH) can be used to characterize the telomere length of hematopoietic cells. This review describes recent advances in the molecular characterization of telomere system, the regulation of telomerase activity in cancer pathogenesis and shows that the telomeric length could be a potential clinical marker of hematologic neoplasia and prognosis of disease. (en)
Title
  • The role of telomeres and telomerase complex in haematological neoplasia : the length of telomeres as a marker of carcinogenesis and prognosis of disease
  • The role of telomeres and telomerase complex in haematological neoplasia : the length of telomeres as a marker of carcinogenesis and prognosis of disease (en)
skos:prefLabel
  • The role of telomeres and telomerase complex in haematological neoplasia : the length of telomeres as a marker of carcinogenesis and prognosis of disease
  • The role of telomeres and telomerase complex in haematological neoplasia : the length of telomeres as a marker of carcinogenesis and prognosis of disease (en)
skos:notation
  • RIV/00023736:_____/10:00008343!RIV11-MZ0-00023736
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(LC535), V, Z(MSM0021620808), Z(MZ0VFN2005)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...dnocenehoVysledku
  • 285756
http://linked.open...ai/riv/idVysledku
  • RIV/00023736:_____/10:00008343
http://linked.open...riv/jazykVysledku
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  • telomere; telomerase; leukemia; senescence (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [1116A2BBC85F]
http://linked.open...i/riv/nazevZdroje
  • Prague Medical Report
http://linked.open...in/vavai/riv/obor
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 111
http://linked.open...iv/tvurceVysledku
  • Březinová, Jana
  • Zemanová, Z.
  • Michalová, K.
  • Včelíková, Soňa
  • Gančarčíková, M.
  • Šmigová, J.
http://linked.open...n/vavai/riv/zamer
issn
  • 1214-6994
number of pages
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