About: Identification of molecular targets for selective elimination of TRAIL-resistant leukemia cells : from spots to in vitro assays using TOP15 charts

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We derived two TRAIL-resistant HL-60 subclones, HL-60/P1 and HL-60/P2, from a TRAIL-sensitive HL-60 acute promyelocytic leukemia cell line and performed expression proteomics analysis. We identified potential molecular targets for selective elimination of resistant cells and proposed and successfuly tested several treatments leading to selective elimination of TRAIL-resistant cells. We derived two TRAIL-resistant HL-60 subclones, HL-60/P1 and HL-60/P2, from a TRAIL-sensitive HL-60 acute promyelocytic leukemia cell line and performed expression proteomics analysis. We identified potential molecular targets for selective elimination of resistant cells and proposed and successfuly tested several treatments leading to selective elimination of TRAIL-resistant cells. (en)
Title	Identification of molecular targets for selective elimination of TRAIL-resistant leukemia cells : from spots to in vitro assays using TOP15 charts Identification of molecular targets for selective elimination of TRAIL-resistant leukemia cells : from spots to in vitro assays using TOP15 charts (en)
skos:prefLabel	Identification of molecular targets for selective elimination of TRAIL-resistant leukemia cells : from spots to in vitro assays using TOP15 charts Identification of molecular targets for selective elimination of TRAIL-resistant leukemia cells : from spots to in vitro assays using TOP15 charts (en)
skos:notation	RIV/00023736:_____/09:00008264!RIV10-MZ0-00023736
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/07/0830), P(GA305/09/1390), P(LC06044), P(NR8317), P(NR8930), Z(AV0Z50200510), Z(MSM0021620806), Z(MSM0021620808), Z(MZ0UHKT2005)
http://linked.open...iv/cisloPeriodika	22
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Klener, Pavel Petrák, Jiří Toman, Ondřej Čmejla, Radek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	318351
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/09:00008264
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	biomedicine; Drug resistance; HL-60; leukemia; TOP15; TRAIL (en)
http://linked.open.../riv/klicoveSlovo	HL-60 leukemia TRAIL Drug resistance biomedicine TOP15
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[47860A2ED7D0]
http://linked.open...i/riv/nazevZdroje	Proteomics
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Regulatory mechanisms of growth and apoptosis of primary leukemia progenitor/stem cells. Proteomic diagnosis of onkologic disaeses in gynecology Center for Experimental Hematology Investigation of metabolic mechanisms of heart failure progression in an experimental model Iron metabolism and cellular cytoskeleton: defining a new role for MRCK?
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Halada, P. Klener, Pavel Petrák, Jiří Toman, Ondřej Živný, J. Čmejla, Radek Šimonová, T.
http://linked.open...ain/vavai/riv/wos	000272391300001
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu Význam molekulárně biologických vyšetření pro objasnění patogeneze a pro diagnostiku poruch krvetvorby a využití krvetvorné buňky v léčbě onemocnění krvetvorby a jiných tkání.
issn	1615-9853
number of pages	10 (xsd:int)

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