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  • Oncoprotein BCR-ABL that is responsible for the pathophysiology of chronic myelogenous leukemia (CML) affects the RhoA/ROCK/LIM/cofilin pathway that regulates the actin cytoskeleton assembly and thereby the cellular adhesion and migration. The review deals with the known points interference between BCR-ABL protein and Rho kinase signaling pathways and with the effects of the drug Imatinib mesylate on Rho signaling and CML cells adhesion to extracellular matrix compounds.
  • Oncoprotein BCR-ABL that is responsible for the pathophysiology of chronic myelogenous leukemia (CML) affects the RhoA/ROCK/LIM/cofilin pathway that regulates the actin cytoskeleton assembly and thereby the cellular adhesion and migration. The review deals with the known points interference between BCR-ABL protein and Rho kinase signaling pathways and with the effects of the drug Imatinib mesylate on Rho signaling and CML cells adhesion to extracellular matrix compounds. (en)
  • Onkoprotein BCR-ABL, jenž je zodpovědný za patofysiologii chronické myeloidní leukémie (CML), ovlivňuje signální dráhu RhoA/ROCK/LIM/kofilin, jež reguluje sestavu aktinového cytoskeletu a tudíž buněčnou adhezi a migraci. Přehledný referát pojednává o známých místech interference mezi proteinem BCR-ABL a signálními dráhami Rho a o účincích léčiva Imatinib mesylátu na signalizaci Rho a adhezi buněk CML ke složkám extracelulární matrice. (cs)
Title
  • Rho-signaling pathways in chronic myelogenous leukemia
  • Signální dráhy Rho u chronické myeloidní leukémie (cs)
  • Rho-signaling pathways in chronic myelogenous leukemia (en)
skos:prefLabel
  • Rho-signaling pathways in chronic myelogenous leukemia
  • Signální dráhy Rho u chronické myeloidní leukémie (cs)
  • Rho-signaling pathways in chronic myelogenous leukemia (en)
skos:notation
  • RIV/00023736:_____/08:00007755!RIV09-MZ0-00023736
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NR9243)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 392811
http://linked.open...ai/riv/idVysledku
  • RIV/00023736:_____/08:00007755
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • CML; BCR-ABL; adhesion; Rho GTPase (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [DAC5092044D2]
http://linked.open...i/riv/nazevZdroje
  • Cardiovascular & Hematological Disorders : Drug Targets
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 8
http://linked.open...iv/tvurceVysledku
  • Hrkal, Zbyněk
  • Kuželová, Kateřina
issn
  • 1871-529X
number of pages
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