About: Imatinib mesylate affects tyrosine kinase activity in both leukemic and normal primary mononuclear blood cells     Goto   Sponge   Distinct   Permalink

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Description
  • Byla měřena tyrosin-kinázová (TK) aktivita a hladina fosfotyrosinu mononukleárních buněk pacientů s chronickou myeloidní leukémií (CML) a normálních zdravých dárců. Ošetření CML buněk Imatinib mesylátem významně snížilo TK aktivitu paralelně se snížením hladiny fosfotyrosinu. Změna tyrosin-kinázové aktivity byla pozorována též u zdravých dárců. Imatinib mesylát pravděpodobně ovlivňuje buněčnou signalizaci i u BCR-ABL negativních buněk (cs)
  • The tyrosine kinase activity and phosphotyrosine level were measured in mononuclear cells of chronic myelogenous leukemia (CML) patients as well as normal healthy donors. Imatinib mesylate treatment significantly reduced TK activity in parallel with the decrease of phosphotyrosine level. The change in tyrosine-kinase activity has also been observed in the healthy donors group. Imatinib mesylate probably affects cell signalization even in BCR-ABL negative cells
  • The tyrosine kinase activity and phosphotyrosine level were measured in mononuclear cells of chronic myelogenous leukemia (CML) patients as well as normal healthy donors. Imatinib mesylate treatment significantly reduced TK activity in parallel with the decrease of phosphotyrosine level. The change in tyrosine-kinase activity has also been observed in the healthy donors group. Imatinib mesylate probably affects cell signalization even in BCR-ABL negative cells (en)
Title
  • Imatinib mesylate affects tyrosine kinase activity in both leukemic and normal primary mononuclear blood cells
  • Imatinib mesylate affects tyrosine kinase activity in both leukemic and normal primary mononuclear blood cells (en)
  • Imatinib mesylate ovlivňuje tyrosin-kinázovou aktivitu v leukemických i normálních primárních mononukleárních krevních buňkách (cs)
skos:prefLabel
  • Imatinib mesylate affects tyrosine kinase activity in both leukemic and normal primary mononuclear blood cells
  • Imatinib mesylate affects tyrosine kinase activity in both leukemic and normal primary mononuclear blood cells (en)
  • Imatinib mesylate ovlivňuje tyrosin-kinázovou aktivitu v leukemických i normálních primárních mononukleárních krevních buňkách (cs)
skos:notation
  • RIV/00023736:_____/06:00006618!RIV07-MZ0-00023736
http://linked.open.../vavai/riv/strany
  • 95;104
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NL7681)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 478851
http://linked.open...ai/riv/idVysledku
  • RIV/00023736:_____/06:00006618
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • tyrosine-kinase activity; Imatinib; K562; primary blood cells; leukemia (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [16B37E98ADC2]
http://linked.open...i/riv/nazevZdroje
  • Journal of Applied Biomedicine : JAB
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 4
http://linked.open...iv/tvurceVysledku
  • Hrkal, Zbyněk
  • Klamová, Hana
  • Marinov, Iuri
  • Grebeňová, Dana
  • Kuželová, Kateřina
  • Pluskalová, Michaela
issn
  • 1214-021X
number of pages
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