About: Leukemic cells treated with photodynamic therapy (ALA-PDT) exhibit different cell response in the expression and/or phosphorylation of some heat shock proteins.     Goto   Sponge   Distinct   Permalink

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Description
  • Metodou dvojrozměrné elektroforézy byly studovány účinky fotodynamické terapie, ALA-PDT, na leukemické buněčné linie HL60 a K562. Hmotnostní spektrometrií (MALDI-TOF) byly identifikovány proteiny, jež byly ALA-PDT ovlivněny, kromě jiných chaperony HSP60 a HSP90. ALA-PDT indukovala v buňkách K562 fosforylaci HSP90 vedoucí k destabilizaci klientního (onko)proteinu BCR-ABL a jeho degradaci proteasomem. (cs)
  • By means of two-dimensional electrophoresis the effects of photodynamic therapy, ALA-PDT, were studied on leukemia cell lines HL60 and K562. By mass spectrometry (MALDI-TOF) the proteins affected by ALA-PDT were identified, among others the chaperones HSP60 and HSP90. ALA-PDT induced phosphorylation of HSP90 leading to the destabilization of the client (onco)protein BCR-ABL and its proteasomal degradation.
  • By means of two-dimensional electrophoresis the effects of photodynamic therapy, ALA-PDT, were studied on leukemia cell lines HL60 and K562. By mass spectrometry (MALDI-TOF) the proteins affected by ALA-PDT were identified, among others the chaperones HSP60 and HSP90. ALA-PDT induced phosphorylation of HSP90 leading to the destabilization of the client (onco)protein BCR-ABL and its proteasomal degradation. (en)
Title
  • Leukemic cells treated with photodynamic therapy (ALA-PDT) exhibit different cell response in the expression and/or phosphorylation of some heat shock proteins.
  • Leukemic cells treated with photodynamic therapy (ALA-PDT) exhibit different cell response in the expression and/or phosphorylation of some heat shock proteins. (en)
  • -činky fotodynamické terapie (ALA-PDT) a rozdílné reakce buněk v expresi a/nebo fosforylaci některých proteinů. (cs)
skos:prefLabel
  • Leukemic cells treated with photodynamic therapy (ALA-PDT) exhibit different cell response in the expression and/or phosphorylation of some heat shock proteins.
  • Leukemic cells treated with photodynamic therapy (ALA-PDT) exhibit different cell response in the expression and/or phosphorylation of some heat shock proteins. (en)
  • -činky fotodynamické terapie (ALA-PDT) a rozdílné reakce buněk v expresi a/nebo fosforylaci některých proteinů. (cs)
skos:notation
  • RIV/00023736:_____/04:I0000058!RIV/2005/MZ0/L33005/N
http://linked.open.../vavai/riv/strany
  • 183-184
http://linked.open...avai/riv/aktivita
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  • P(NL7681)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
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  • 571439
http://linked.open...ai/riv/idVysledku
  • RIV/00023736:_____/04:I0000058
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  • HL60;K562;two-dimensional electrophoresis;photodynamic therapy;ALA-PDT;HSP90;BCR-ABL (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [8081F8E4890F]
http://linked.open...i/riv/mistoVydani
  • Olomouc
http://linked.open...i/riv/nazevZdroje
  • Frébort, I., Walterová D. (ed.). Chemica 43S : supplement collected reports of the Natural science faculty, Palacký Univerzity Olomouc, Czech Republic
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Halada, P.
  • Hrkal, Zbyněk
  • Grebeňová, Dana
  • Pluskalová, Michaela
number of pages
http://purl.org/ne...btex#hasPublisher
  • Univerzita Palackého v Olomouci – Vydavatelství
https://schema.org/isbn
  • 80-244-0882-1
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