About: Fast apoptosis and erythroid differentiation induced by imatinib mesylate in JURL-MK1 cells.     Goto   Sponge   Distinct   Permalink

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  • The effects of Imatinib mesylate on CML cell lines K562 and JURL-MK1 were compared. Imatinib mesylate arrested both cell lines in G0/G1 phase and induced apoptosis that proceeded faster in JURL-MK1 cells and occurred in larger fraction of cell population. In addition, the erythroid differentiation was triggered in both cell lines. Apoptosis and the erythroid differentiation are parallel effects of Imatinib mesylate and their relative contributions and kinetics are related to the differentiation stage of treated cells.
  • The effects of Imatinib mesylate on CML cell lines K562 and JURL-MK1 were compared. Imatinib mesylate arrested both cell lines in G0/G1 phase and induced apoptosis that proceeded faster in JURL-MK1 cells and occurred in larger fraction of cell population. In addition, the erythroid differentiation was triggered in both cell lines. Apoptosis and the erythroid differentiation are parallel effects of Imatinib mesylate and their relative contributions and kinetics are related to the differentiation stage of treated cells. (en)
  • Byly porovnány účinky Imatinib mesylátu na CML buněčné linie K562 a JURL-MK1. U obou linií došlo k zastavení buněčného cyklu v G0/G1 fázi a byla indukována apoptoza jež u buněk JURL-MK1 probíhala rychleji a u větší části buněčné populace. Dále byla u obou linií navozena erytroidní diferenciace. Apoptoza a erytroidní diferenciace jsou paralelními účinky Imatinib mesylátu jejichž relativní příspěvky a kinetiky jsou závislé na diferenciačním stavu buněk. (cs)
Title
  • Fast apoptosis and erythroid differentiation induced by imatinib mesylate in JURL-MK1 cells.
  • Rychlá apoptóza a erytroidní diferenciace vyvolané účinkem imatinib mesylátu na buněčné linie K 562 a JURL-MK1 (cs)
  • Fast apoptosis and erythroid differentiation induced by imatinib mesylate in JURL-MK1 cells. (en)
skos:prefLabel
  • Fast apoptosis and erythroid differentiation induced by imatinib mesylate in JURL-MK1 cells.
  • Rychlá apoptóza a erytroidní diferenciace vyvolané účinkem imatinib mesylátu na buněčné linie K 562 a JURL-MK1 (cs)
  • Fast apoptosis and erythroid differentiation induced by imatinib mesylate in JURL-MK1 cells. (en)
skos:notation
  • RIV/00023736:_____/04:I0000035!RIV/2005/MZ0/L33005/N
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  • 36
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  • P(NL7681)
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  • 564173
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  • RIV/00023736:_____/04:I0000035
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  • Imatinib mesylate;STI571;leukemia;apoptosis;erythroid differentiation (en)
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  • [AAE7D1E3A5C0]
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  • Cascais
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  • Cascais
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  • 5th interdisciplinary conference mechanisms of cell death and disease : advances in therapeutic intervention and drug development
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  • Hrkal, Zbyněk
  • Grebeňová, Dana
  • Kuželová, Kateřina
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  • ESH and MD Anderson Cancer Center
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