About: Combined inhibition of 20-hydroxyeicosatetrenoic acid formation and epoxyeicosaetraenoic degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats.

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About: Combined inhibition of 20-hydroxyeicosatetrenoic acid formation and epoxyeicosaetraenoic degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats. Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Recent studies have shown that the renal CYP450 (cytochrome P450) metabolites of AA (arachidonic acid), the vasoconstrictor 20-HETE (20-hydroxyeicosatetraenoic acid) and the vasodilator EETs (epoxyeicosatrienoic acids), play an important role in the pathophysiology of AngII (angiotensin II)-dependent forms of hypertension and the associated target organ damage. The present studies were performed in Ren-2 renin transgenic rats (TGR) to evaluate the effects of chronic selective inhibition of 20-HETE formation or elevation of the level of EETs, alone or in combination, on the course of hypertension and hypertension-associated end-organ damage. Both young (30 days of age) prehypertensive TGR and adult (190 days of age) TGR with established hypertension were examined. Normotensive HanSD (Hannover Sprague-Dawley) rats served as controls. The rats were treated with N-methylsulfonyl-12,12-dibromododec-11-enamide to inhibit 20-HETE formation and/or with N-cyclohexyl-N-dodecyl urea to inhibit soluble epoxide hy Recent studies have shown that the renal CYP450 (cytochrome P450) metabolites of AA (arachidonic acid), the vasoconstrictor 20-HETE (20-hydroxyeicosatetraenoic acid) and the vasodilator EETs (epoxyeicosatrienoic acids), play an important role in the pathophysiology of AngII (angiotensin II)-dependent forms of hypertension and the associated target organ damage. The present studies were performed in Ren-2 renin transgenic rats (TGR) to evaluate the effects of chronic selective inhibition of 20-HETE formation or elevation of the level of EETs, alone or in combination, on the course of hypertension and hypertension-associated end-organ damage. Both young (30 days of age) prehypertensive TGR and adult (190 days of age) TGR with established hypertension were examined. Normotensive HanSD (Hannover Sprague-Dawley) rats served as controls. The rats were treated with N-methylsulfonyl-12,12-dibromododec-11-enamide to inhibit 20-HETE formation and/or with N-cyclohexyl-N-dodecyl urea to inhibit soluble epoxide hy (en)
Title	Combined inhibition of 20-hydroxyeicosatetrenoic acid formation and epoxyeicosaetraenoic degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats. Combined inhibition of 20-hydroxyeicosatetrenoic acid formation and epoxyeicosaetraenoic degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats. (en)
skos:prefLabel	Combined inhibition of 20-hydroxyeicosatetrenoic acid formation and epoxyeicosaetraenoic degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats. Combined inhibition of 20-hydroxyeicosatetrenoic acid formation and epoxyeicosaetraenoic degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats. (en)
skos:notation	RIV/00023001:_____/10:00002317!RIV11-MZ0-00023001
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(GA305/07/0167), P(GC305/07/J004), P(GC305/08/J006), P(IAA511700701), P(NS10499), P(NS10500), P(NS9699), S, Z(MZ0IKEM2005)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Vaňourková, Zdeňka Červenka, Luděk Vaněčková, Ivana Kopkan, Libor Kujal, Petr Vernerová, Zdeňka Chábová, Věra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	251218
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/10:00002317
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cytochrome P450; end-organ damage; hypertension; renin-angiotensin system; soluble epoxide hydrolase (en)
http://linked.open.../riv/klicoveSlovo	renin-angiotensin system soluble epoxide hydrolase hypertension - ischaemic heart disease - cardiac failure - vitamin D end-organ damage cytochrome P450
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[78C115F0B976]
http://linked.open...i/riv/nazevZdroje	Clinical science
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	14 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of increased epoxyeicosatrienoic acids level in the regulation of renal function and pathophysiology of renovascular hypertension The role of angiotensin II type 2 receptors in the pathophysiology of renovascular hypertension The roles of renin-angiotensin and endothelin systems in the pathophysiology of ANG II-dependent hypertension The role of impaired renal autoregulation and the tissue renin-angiotensin-aldosterone system in the pathophysiology of chronic renal failure The role of impairment of pressure-natriuresis mechanism in the pathophysiology of angiotensin II-dependent malignant form of hypertension The interaction between renin-angiotensin and endothelin systems in the pathogenesis of renal failure and cardiac hypertrophy in hypertensive rats The role of angiotensin-(1-7), a new component of the renin-angiotensin system, in the pathophysiology of two-kidney one-clip Goldblatt hypertension
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	118
http://linked.open...iv/tvurceVysledku	Vaněčková, Ivana Vaňourková, Zdeňka Červenka, Luděk Kopkan, Libor Kujal, Petr Vernerová, Zdeňka Imig, John D. Kramer, Herbert J. Hammock, Bruce D. Čertíková-Chábová, Věra Falck, John R. Kompanowska-Jezierska, Elzbieta Sadowski, Janusz Walkowska, Agnieszka
http://linked.open...ain/vavai/riv/wos	000277900600007
http://linked.open...n/vavai/riv/zamer	Výzkum kardiovaskulárních nemocí, diabetu a transplantace životně důležitých orgánů
issn	0143-5221
number of pages	16 (xsd:int)

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