AttributesValues
rdf:type
Description
  • The temporal relationship of hepatic steatosis and changes in liver oxidative stress and fatty acid (FA) composition to the development of non-alcoholic steatohepatitis (NASH) remain to be clearly defined. Recently, we developed an experimental model of hepatic steatosis and NASH, the transgenic spontaneously hypertensive rat (SHR) that overexpresses a dominant positive form of the human SREBP-1a isoform in the liver. These rats are genetically predisposed to hepatic steatosis at a young age that ultimately progresses to NASH in older animals. Young transgenic SHR versus SHR controls exhibited simple hepatic steatosis which was associated with significantly increased hepatic levels of oxidative stress markers, conjugated dienes, and TBARS, with decreased levels of antioxidative enzymes and glutathione and lower concentrations of plasma ?- and ?-tocopherol. Transgenic rats exhibited increased plasma levels of saturated FA, decreased levels of n-3 and n-6 polyunsaturated FA (PUFA), and increas
  • The temporal relationship of hepatic steatosis and changes in liver oxidative stress and fatty acid (FA) composition to the development of non-alcoholic steatohepatitis (NASH) remain to be clearly defined. Recently, we developed an experimental model of hepatic steatosis and NASH, the transgenic spontaneously hypertensive rat (SHR) that overexpresses a dominant positive form of the human SREBP-1a isoform in the liver. These rats are genetically predisposed to hepatic steatosis at a young age that ultimately progresses to NASH in older animals. Young transgenic SHR versus SHR controls exhibited simple hepatic steatosis which was associated with significantly increased hepatic levels of oxidative stress markers, conjugated dienes, and TBARS, with decreased levels of antioxidative enzymes and glutathione and lower concentrations of plasma ?- and ?-tocopherol. Transgenic rats exhibited increased plasma levels of saturated FA, decreased levels of n-3 and n-6 polyunsaturated FA (PUFA), and increas (en)
Title
  • Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitits in SREBP-1a spontaneously hypertensive rats with predisposition to hepatic steatosis
  • Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitits in SREBP-1a spontaneously hypertensive rats with predisposition to hepatic steatosis (en)
skos:prefLabel
  • Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitits in SREBP-1a spontaneously hypertensive rats with predisposition to hepatic steatosis
  • Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitits in SREBP-1a spontaneously hypertensive rats with predisposition to hepatic steatosis (en)
skos:notation
  • RIV/00023001:_____/10:00002190!RIV11-MZ0-00023001
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(IAA500110604), P(NR9359), P(NR9387), P(NS9696), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika
  • 1-2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 263367
http://linked.open...ai/riv/idVysledku
  • RIV/00023001:_____/10:00002190
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • steatohepatitis; trangenic rats; SREBP-1a; dyslipidemia; PUFA (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [CABA9FF10DB8]
http://linked.open...i/riv/nazevZdroje
  • Molecular and cellular biochemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 335
http://linked.open...iv/tvurceVysledku
  • Kazdová, Ludmila
  • Oliyarnyk, Olena
  • Mlejnek, P.
  • Malínská, Hana
  • Landa, V.
  • Pravenec, M.
  • Zídek, V.
  • Hubová, Miriam
  • Šimáková, M.
http://linked.open...ain/vavai/riv/wos
  • 000273812100014
http://linked.open...n/vavai/riv/zamer
issn
  • 0300-8177
number of pages
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