About: Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitits in SREBP-1a spontaneously hypertensive rats with predisposition to hepatic steatosis

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About: Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitits in SREBP-1a spontaneously hypertensive rats with predisposition to hepatic steatosis Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The temporal relationship of hepatic steatosis and changes in liver oxidative stress and fatty acid (FA) composition to the development of non-alcoholic steatohepatitis (NASH) remain to be clearly defined. Recently, we developed an experimental model of hepatic steatosis and NASH, the transgenic spontaneously hypertensive rat (SHR) that overexpresses a dominant positive form of the human SREBP-1a isoform in the liver. These rats are genetically predisposed to hepatic steatosis at a young age that ultimately progresses to NASH in older animals. Young transgenic SHR versus SHR controls exhibited simple hepatic steatosis which was associated with significantly increased hepatic levels of oxidative stress markers, conjugated dienes, and TBARS, with decreased levels of antioxidative enzymes and glutathione and lower concentrations of plasma ?- and ?-tocopherol. Transgenic rats exhibited increased plasma levels of saturated FA, decreased levels of n-3 and n-6 polyunsaturated FA (PUFA), and increas The temporal relationship of hepatic steatosis and changes in liver oxidative stress and fatty acid (FA) composition to the development of non-alcoholic steatohepatitis (NASH) remain to be clearly defined. Recently, we developed an experimental model of hepatic steatosis and NASH, the transgenic spontaneously hypertensive rat (SHR) that overexpresses a dominant positive form of the human SREBP-1a isoform in the liver. These rats are genetically predisposed to hepatic steatosis at a young age that ultimately progresses to NASH in older animals. Young transgenic SHR versus SHR controls exhibited simple hepatic steatosis which was associated with significantly increased hepatic levels of oxidative stress markers, conjugated dienes, and TBARS, with decreased levels of antioxidative enzymes and glutathione and lower concentrations of plasma ?- and ?-tocopherol. Transgenic rats exhibited increased plasma levels of saturated FA, decreased levels of n-3 and n-6 polyunsaturated FA (PUFA), and increas (en)
Title	Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitits in SREBP-1a spontaneously hypertensive rats with predisposition to hepatic steatosis Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitits in SREBP-1a spontaneously hypertensive rats with predisposition to hepatic steatosis (en)
skos:prefLabel	Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitits in SREBP-1a spontaneously hypertensive rats with predisposition to hepatic steatosis Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitits in SREBP-1a spontaneously hypertensive rats with predisposition to hepatic steatosis (en)
skos:notation	RIV/00023001:_____/10:00002190!RIV11-MZ0-00023001
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA500110604), P(NR9359), P(NR9387), P(NS9696), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Oliyarnyk, Olena Brátová, Miriam Malínská, Hana Kazdová, Ludmila
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	263367
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/10:00002190
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	steatohepatitis; trangenic rats; SREBP-1a; dyslipidemia; PUFA (en)
http://linked.open.../riv/klicoveSlovo	PUFA steatohepatitis SREBP-1a trangenic rats dyslipidemia
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[CABA9FF10DB8]
http://linked.open...i/riv/nazevZdroje	Molecular and cellular biochemistry
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanisms and consequences of the accumulation of lipids in liver associated with metabolic syndrome - the possibilities of nutritional and pharmacological intervention Pathophysiology and genetics of metabolic syndrome in experimental models and humans The role of adipocytokines and fatty acids in the disorders of insulin sensitivity and insulin secretion in metabolic syndrome Pathogenesis of spontaneous hypertension: integrated analysis of intermediary phenotypes of autonomic/sympathetic system and gene expression profiles in rat recombinant inbred strains
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	335
http://linked.open...iv/tvurceVysledku	Kazdová, Ludmila Oliyarnyk, Olena Mlejnek, P. Malínská, Hana Landa, V. Pravenec, M. Zídek, V. Hubová, Miriam Šimáková, M.
http://linked.open...ain/vavai/riv/wos	000273812100014
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0300-8177
number of pages	7 (xsd:int)

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