About: Complex analysis of p53 mutants in lymphoproliferative diseases     Goto   Sponge   Distinct   Permalink

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  • We propose to perform complex analysis of the p53 tumor suppressor in tumor tissues of MCL and DLBCL patients aiming to extend existing panels of patients (from 42 to 70 in MCL and from 75 to 140 in DLBCL) and to determine the prognostic value of p53 mutations in these diseases. For detection of p53 aberrations, we will employ functional analysis of separated alleles in yeast (FASAY) and immunoblotting; detection of the 17p13 locus will be performed by FISH. Newly identified p53 mutations as well as some earlier detected ones, especially those connected with nonsense-mediated mRNA decay will be analyzed in detail. (en)
  • Navrhujeme komplexní analýzu nádorového supresoru p53 v nádorové tkáni pacientů s MCL a DLBCL s cílem rozšířit stávající soubory pacientů (ze 42 na 70 u MCL a ze 75 na 140 u DLBCL) a zjistit prognostickou hodnotu p53 u tohoto onemocnění. K detekci aberací použijeme funkční analýzu separovaných alel v kvasinkách, sekvenování DNA, imunohistochemickou analýzu hladiny proteinu p53 a imunobloting, k detekci delece lokusu 17p13 metodu FISH. Podrobně budeme analyzovat nově zachycené mutace p53 a také některé již dříve detekované mutace, především soubor mutací spojených s mechanismem nonsense-mediated mRNA decay.
Title
  • Complex analysis of p53 mutants in lymphoproliferative diseases (en)
  • Komplexní analýza mutantů p53 u lymfoproliferativních onemocnění
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  • NT13784
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  • diffuse large B-cell lymphoma; mantle cell lymphoma; tumor suppressor p53; FASAY; nonsense-mediated mRNA decay (en)
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  • diffuse large B-cell lymphoma
  • tumor suppressor p53
  • FASAY
  • mantle cell lymphoma
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