About: Biology and treatment of high-risk TEL/ABL-positive childhood acute lymphoblastic leukaemia     Goto   Sponge   Distinct   Permalink

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Description
  • The frequency and adverse prognosis of TEL/ABL-positive childhood acute lymphoblastic leukaemias have so far been underrated. Discovering the circumstances of the development of the TEL/ABL-positive (pre)leukaemic clone, biological attributes and the mechanisms of its sensitivity and resistance to the targeted treatment of the TEL/ABL-positive ALL will contribute towards improving the treatment of the paediatric patients from this group, who have so far faced a particularly unfavourable prognosis. (en)
  • Frekvence a nepříznivá prognosa TEL/ABL-positivních dětských akutních lymfoblastických leukemií byla dosud podceněna. Odhalení okolností vývoje TEL/ABL-positivního (pre)leukemického klonu, biologických vlastností a mechanismů citlivosti a resistence na cílenou léčbu TEL/ABL-positivní ALL přispěje ke zlepšení léčebných výsledků této prognosticky velmi nepříznivé skupiny dětských pacientů.
Title
  • Biology and treatment of high-risk TEL/ABL-positive childhood acute lymphoblastic leukaemia (en)
  • Biologie a léčba vysoce rizikové TEL/ABL-positivní dětské akutní lymfoblastické leukemie
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  • NT13170
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  • Childhood acute lymphoblastic; TEL/ABL; tyrosin kinase inhibitors (en)
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  • TEL/ABL
  • Childhood acute lymphoblastic
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