About: The effect of histone deacetylase inhibitors on TEL/AML1 - positive leukaemic cells     Goto   Sponge   Distinct   Permalink

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  • Using histone deacetylase inhibitors, we will study chromatin remodelling leading to apoptosis and differentiation of TEL/AML1-positive leukaemic cells. We will analyse in vitro effect of this therapy on the changes of cell cycle and the gene expression in leukaemic cells. (en)
  • Pomocí inhibitorů deacetylas histonů způsobíme remodelaci chromatinu vedoucí k apoptose a diferenciaci TEL/AML1 positivních leukemických buněk. Budeme in vitro analysovat vliv této léčby na změny buněčného cyklu a genové exprese v leukemických buňkách.
Title
  • The effect of histone deacetylase inhibitors on TEL/AML1 - positive leukaemic cells (en)
  • Vliv inhibitorů deacetylas histonů na TEL/AML1 positivní leukemické buňky
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  • NR8316
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  • Childhood acute leukaemias; TEL/AML1; histone deacetylase inhibitors; chromatin; remodelling (en)
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  • New knowledge for hematology, treatment of ALL and explanation of HDACi effects. Apoptosis and cell cycle by using HDACi was proved in cells with TEL/AML1 Other genes sharing on the regulation of proliferation and dif of TEL/AML1 cells have been found. (en)
  • Výsledky přinesly nové poznatky do hematoonkologie,léčby ALL a objasnění účinků HDACi. V buňkách s TEL/AML1 byla prokázána zástava buněčného cyklu a apoptozy pomocí HDACi. Zjištěny další geny podílející se na regulaci proliferace a dif. TEL/AML1 buněk. (cs)
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  • chromatin
  • TEL/AML1
  • histone deacetylase inhibitors
  • Childhood acute leukaemias
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