About: The study of molecular defects of cancer cell in the transduction pathways of interferon signals mediated by STAT 1/SOCS 3 proteins and their significance for the prediction of tumor sensitivity to interferon therapy.     Goto   Sponge   Distinct   Permalink

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Description
  • Project intends to explore whether and to what extend cancer-related impaired interferon transduction pathways ensured by STAT 1 and SOCS 3 protein functions and interactions affect the response of malignant melanoma to IFN-alpha/gamma treatment The level of STAT 1/ SOCS 3 proteins, their mRNAs, and STAT 1 phosphorylated forms induced by IFNs in melanoma and normal cells will be examined using immunoblotting, MTT and morphological assays, and correlated with the interferon biological effects. It is expected to define newě markers which might predict responsiveness to interferon treatment in individual patients and to gain new data about IFN-induced STAT 1/SOCS 3 interactions in normal and malignant cancer cells. (en)
  • Projekt je zaměřen na analýzu patologických změn v přenosu interferonových signálů v nádorové buňce a jejich souvislosti s citlivostí nádoru na léčbu interferony. Na úrovni proteinů a mRNA studuje expresi transdukčního proteinu STAT 1, jeho interferony indukovaných fosfoforem a jeho interakce s inhibitorem SOCS 3 u maligního melanomu v korelaci s parametry v normální tkáni a s biologickými účinky IFN-alfa/gama. Metodickým základem je připrava imunosond proti SOCS 3 peptidu, Western a Northern blot, imunoprecipitace, MTT test a morfologická analýza buněčného poškození.
Title
  • The study of molecular defects of cancer cell in the transduction pathways of interferon signals mediated by STAT 1/SOCS 3 proteins and their significance for the prediction of tumor sensitivity to interferon therapy. (en)
  • Studium molekulárních defektů nádorové buňky v transdukčních drahách interferonových signálů, mediovaných proteiny STAT 1/SOCS 3, a význam jejich stanovení pro predikci citlivosti nádoru na léčbu interferony.
skos:notation
  • NC7139
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  • STAT 1;COCS 3;interferons (IFNs);malignant melanoma;signal transduction (en)
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  • Findings of deficient interferon activation of protein STAT1 in malignant process, positive correlation between the STAT1 activation defect after INFgama and course of disease. No regulation of expression of SOCS3 by phosphorylation of STAT1 was found. (en)
  • Poznatky o nedostatečné interferonové aktivaci proteinu STAT1 a její souvislosti s maligním procesem, pozitivní korelace mezi poruchou STAT1 aktivace po INFgama a průběhem onemocnění. Zjištění, že exprese SOCS3 proteinu není regulována fosforylací STAT1. (cs)
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  • malignant melanoma
  • COCS 3
  • STAT 1
  • interferons (IFNs)
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