About: New glycosynthases and their use in glycoconjugates synthesis     Goto   Sponge   Distinct   Permalink

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Description
  • The aim of this project is obtaining by mutagenesis microbial galactosynthase that will be able to catalyse transglycosylation of donors prepared by chemical synthesis. Thus obtain new glycoconjugates with furanose suitable for pharmaceutical use. (en)
  • Cílem projektu je získat pomocí cílené mutagenese mikrobiální galaktosynthasu, jež by byla schopna katalyzovat transglykosylaci donorů připravených chemickou syntézou. Tímto způsobem získat konjugáty obsahující furanosu, které by byly vhodné pro farmaceutické účely.
Title
  • New glycosynthases and their use in glycoconjugates synthesis (en)
  • Nové glykosynthasy a jejich využití pro syntézu glykokonjugátů
skos:notation
  • MEB020824
http://linked.open...avai/cep/aktivita
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  • glycosynthases; glycoconjugates; transglycosylation; glycosidic bonds; stereoselectivity; regioselectivity; mutagenesis; furanose; pharmaceutical use (en)
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http://linked.open...inujicichPrijemcu
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  • Byly připraveny neobvyklé glykokonjugáty se sacharidy furanosového typu. Některé z připravených glykokonjugátů prokazovaly schopnost zvyšovat makrofagovou produkci TNF-α. Tato vlastnost by mohla být v budoucnu podstatou jejich využití jako součást vakcín proti závažným chorobám. (cs)
  • Unique furanose-containing glycoconjugates were prepared. Several of them showed an ability to increase the macrophage TNF-α production. This property might be a basis for their future application as a vaccines against serious deseases. (en)
http://linked.open...tniCyklusProjektu
http://linked.open.../cep/klicoveSlovo
  • mutagenesis
  • regioselectivity
  • transglycosylation
  • furanose
  • glycoconjugates
  • glycosidic bonds
  • stereoselectivity
  • glycosynthases
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