About: Determination of important pharmacokinetic and biochemical parameters and evaluation of blood-brain barrier penetration using drugs introduced to Czech Army     Goto   Sponge   Distinct   Permalink

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Description
  • The aim of this project is to charakterize pharmacokinetics of substances using in therapy by intoxications. Mainly their distribution in body tissues, in vitro and in vivo testing of ability to penetrate into central nervous system and their possibility to injury brain. At the same time we will evaluate some important biochemical data, which can be influenced by this therapy. (en)
  • Cílem projektu je definovat farmakokinetiku jednotlivých terapeuticky účinných látek, jejich distribuci v organismu, in vitro a in vivo prostup do centrálního nervového systému a možné následovné poškození mozku, způsobené těmito látkami. Zároveň doplnit studii o hodnocení důležitých biochemických markerů, jež by mohly být po podání těchto látek ovlivněny. (cs)
Title
  • FARMAKO - Stanovení důležitých farmakokinetických a biochemických parametrů a hodnocení průniku do CNS léčiv zavedených do výzbroje AČR (cs)
  • Determination of important pharmacokinetic and biochemical parameters and evaluation of blood-brain barrier penetration using drugs introduced to Czech Army (en)
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  • Antidots in the Czech Army, Pharmacokinetic parameters, Blood-brain bariere, HPLC, Rat (en)
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