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  • In vitro studie prokázaly, že R-enantiomer bikalutamidu je inhibitor CYP 3A4 s menším inhibičním účinkem na aktivitu CYP 2C9, 2C19 a 2D6. I když klinické studie s antipyrinem jako markerem aktivity cytochromu P450 (CYP) neukázaly možnost interakce bikalutamidu, střední expozice midazolamu (AUC) byla zvýšena až o 80% po současném podání bikalutamidu po dobu 28 dnů. (cs)
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