About: http://linked.opendata.cz/resource/sukl/spc/sentence/SPC147473

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About: http://linked.opendata.cz/resource/sukl/spc/sentence/SPC147473_doc-5-2-11-1 Goto Sponge Distinct Permalink

An Entity of Type : salt:Sentence, within Data Space : linked.opendata.cz associated with source document(s)

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salt:hasText	Nejdůležitějšími metabolity v plazmě jsou kyselá forma drospirenonu vzniklá otevřením laktonového kruhu a 4,5-dihydro-drospirenon-3-sulfát, oba vznikají bez účasti systému P450. Drospirenon je in vitro z malé části metabolizován cytochromem P450 3A4 a prokázal schopnost inhibovat tento enzym a dále cytochrom P450 1A1, cytochrom P450 2C9 a cytochrom P450 2C19. Eliminace Rychlost metabolické clearance drospirenonu ze séra je 1,5 ± 0,2 ml/min/kg. (cs)
is salt:hasSentence of	http://linked.opendata.cz/resource/sukl/spc/paragraph/SPC147473_doc-5-2-11

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