About: 2-Fluoropropionyl-labeled Pegylated Dimeric RGD Peptide     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • 2-Fluoropropionyl-labeled Pegylated Dimeric RGD Peptide
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • 2-Fluoropropionyl-labeled Pegylated Dimeric RGD Peptide
NCI_META_CUI
  • CL429826
PDQ_Open_Trial_Search_ID
  • 703212
PDQ_Closed_Trial_Search_ID
  • 703212
FULL_SYN
  • 18F-FPPRGD2ABNCI
  • 18F-FP-PRGD2ABNCI
  • [18F] FPPRGD2ABNCI
  • 2-Fluoropropionyl-labeled Pegylated Dimeric RGD PeptidePTNCI
  • Fluorine 18 ((18)F) FPPRGD2SYNCI
  • 18F-FP-PEG3-RGD2ABNCI
  • PEG3-E[c(RGDyk)]2SYNCI
  • 104150CNNCI
DEFINITION
  • A radiopharmaceutical agent comprised of a pegylated dimeric arginine-glycine-aspartic acid (RGD)-based peptide labeled with 2-fluoropropionyl, with potential alphaVbeta3 integrin imaging activity upon positron emission topography (PET). The RGD moiety of 2-fluoropropionyl-labeled pegylated dimeric RGD peptide targets and binds to alphaVbeta3 integrin. Upon PET imaging, alphaVbeta3 integrin-expressing tumor cells can be visualized and expression levels can be quantified. Compared to other fluorine F 18 labeled RGD-containing peptides, this agent shows increased affinity to alphaVbeta3 integrin, enhanced tumor uptake as well as improved pharmacokinetics. alphaVbeta3 integrin, overexpressed on certain tumor cells and tumor endothelial cells, plays a key role in angiogenesis, tumor proliferation and survival.NCI
code
  • C97336
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