About: Vincristine

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Vincristine
rdfs:subClassOf	Vinca-Domain Binding Agent Vinca Alkaloids nodeID://b722981 nodeID://b722982 nodeID://b722983
Has_Salt_Form	Vincristine Sulfate
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Vincristine
UMLS_CUI	C0042679
CAS_Registry	57-22-7
Accepted_Therapeutic_Use_For	Acute leukemia; Brain tumors; Chronic lymphocytic leukemia; Gestational trophoblastic neoplasms; Head and Neck squamous cell carcinoma; Kaposis sarcoma; Liver cancer; Lymphoma, Hodgkins, Non-Hodgkins; Malignant thymoma; Multiple myeloma; Osteogenic sarcoma; Ovarian cancer; Pheochromocytoma; Retinoblastoma; Rhabdomyosarcoma; Soft tissue sarcoma; Testicular cancer; Wilms tumor
In_Clinical_Trial_For	Myelodysplastic and Myeloproliferative diseases; Neuroblastoma; Osteosarcoma; Rhabdomyosarcoma; Soft Tissue sarcoma; Wilms' Tumor Adrenal Cortex Neoplasms; Brain tumors; Childhood Medulloblastoma; Ependymoma; Ewing's sarcoma; Leukemia; Lymphoma; Glioma(s); Medulloblastoma; Multiple Myeloma;
FDA_UNII_Code	5J49Q6B70F
Contributing_Source	FDA
ALT_DEFINITION	The active ingredient in a drug used to treat acute leukemia. It is used in combination with other drugs to treat Hodgkin disease, non-Hodgkin lymphoma, rhabdomyosarcoma, neuroblastoma, and Wilms tumor. Vincristine is also being studied in the treatment of other types of cancer. It blocks cell growth by stopping cell division. It is a type of vinca alkaloid and a type of antimitotic agent.NCI-GLOSS
Chemical_Formula	C46H56N4O10
Legacy_Concept_Name	Vincristine
CHEBI_ID	CHEBI:28445
FULL_SYN	VincristinePTNCI VincrystineSYNCI LEUROCRISTINESYDTPNSC0067574 VincristineSYNCITCGA 22-OxovincaleukoblastineSNNCI vincristinePTNCI-GLOSSCDR0000045435 LeurocristineSYNCI VincristinePTDCP02166 VCRABNCI VINCRISTINEPTFDA5J49Q6B70F VINCRISTINESYDTPNSC0067574
DEFINITION	A natural alkaloid isolated from the plant Vinca rosea Linn. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04)NCI
code	C933
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