About: Toll-Like Receptor Signaling Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Toll-Like Receptor Signaling Pathway
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	Toll-Like Receptor Signaling Pathway
UMLS_CUI	C1817393
KEGG_ID	hsa04620
ALT_DEFINITION	Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-kappa B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-kappa B and MAPK.KEGG
FULL_SYN	Toll-Like Receptor Signaling PathwayPTNCI Toll-like receptor signaling pathwayPTKEGG
code	C91505
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